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Three neck pain-related constructs were explored, relating to severity (mild, moderate, and severe categories were defined from a zero to 10 numerical rating scale for neck pain intensity [24]), self-reported change (much better, better, same, worse, or much worse) and tertile-defined groups for [http://en.wikipedia.org/wiki/Fluconazole Fluconazole] the Northwick Park Neck Pain Questionnaire. Generic constructs focused on self-reported health status (excellent, very good, good, fair, or poor), tertile-defined groups for the EuroQol visual analogue scale (where 100 = best imaginable health state and 0 = worst imaginable health state) [14] and time off work for respondents currently in paid employment (yes or no). Tertile values split the dataset into three equal-sized categories; the lower (upper) category reflects the lowest (highest) third of valid responses. Analysis of the theoretical constructs consisted of computation of category-specific mean scores and appropriate statistical tests (t tests and analysis of variance [ANOVA]) to explore the significance of linear trends. Due to the different scoring ranges of the EQ-5D and SF-6D, the interpretation of mean values reported within theoretically constructed categories was also assessed. The 346 trial participants provided a maximum number of 1038 (3 �� 346) paired EQ-5D and SF-6D responses over the course of the study, which formed the combined dataset. In total, 907 (87%) and 859 (83%) values were observed for the EQ-5D and SF-6D, respectively (see Table 1). For the three distinct time points and the combined sample, ICC values ranged between [http://www.selleckchem.com/products/bgj398-nvp-bgj398.html http://www.selleckchem.com/products/bgj398-nvp-bgj398.html] 0.518 (95% CI 0.43�C0.59) at 6 weeks to 0.550 (95% CI 0.46�C0.63) [http://www.selleckchem.com/products/Paclitaxel(Taxol).html learn more] at 6 months. The Bland and Altman plot for the combined dataset is presented in Figure 1. The width of the 95% limits of agreement was 0.764, which is an estimate of the expected level of variation between future EQ-5D and SF-6D observations. At the lower end of the utility scale, 8% of paired observations were below the lower limit, with less than 1% of observations above the upper limit. Consistent results were observed across all time point-specific analyses (baseline, 6 weeks, and 6 months). At each time point, instrument-completion rates were greater for the EQ-5D than the SF-6D, ranging from a 2% difference at baseline (100% and 98%), to a 7% difference at 6 months (78% and 71%) (see Table 1). A significantly greater proportion of the sample provided valid EQ-5D responses across all three time points (EQ-5D = 74%, SF-6D = 64%; McNemar test, P