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Visual function was assessed with the VF-14 questionnaire. Main Outcome Measures:? Demographics, clinical characteristics and visual function. Results:? Mean age of our patients was 29.5?��?9.40 years on enrolment, 62.9% were male, and the ethnic distribution was 60.3% Chinese, 13.8% Malays and 9.5% Indians. Clinically evident keratoconus was present bilaterally in 65 patients (56.0%) and unilateral keratoconus in five patients (4.3%). Five patients (4.3%) had a family history of keratoconus. The majority of patients were managed [http://en.wikipedia.org/wiki/FKBP FKBP] with contact lenses (60.8%) or glasses (24.5%). Eye rubbing was common (68%) as were asthma (26.3%) and eczema (18.4%). Conical protrusion was the commonest sign (75.3%). The mean cylinder was higher in keratoconus eyes compared with keratoconus suspect eyes (?4.01 vs. ?1.27, P?[http://www.selleckchem.com/products/SRT1720.html SRT1720 mw] in vision-related activities. ""Treatments for angle closure include eye drops, laser procedures, trabeculectomy and other drainage procedures, and now lens extraction. A 2006 Cochrane review of the role of lens extraction in angle closure disease concluded that there was no published evidence supporting the efficacy of lens extraction in chronic primary angle closure glaucoma. More recent randomized controlled trials have suggested greater promise. [http://www.selleckchem.com/products/pexidartinib-plx3397.html Pexidartinib in vivo] We wish to address the rationale, evidence base and philosophy for lens extraction �C especially clear lens extraction �C in preventing vision loss from glaucoma in angle closure disease. ""We describe a case of a 75-year-old man with diabetes type II and end-stage renal disease, presenting with a one-month history of blurring of vision in the left eye. Fundus exam showed pale and swollen optic nerve in the left eye, and temporal artery biopsy showed diffuse and extensive calcification at the internal elastic lamina and media. Biopsy of dusky erythematous lesions over the calves revealed the diagnosis of calciphylaxis. The temporal artery calcific lesions should hence be differentiated from the less extensive atherosclerotic changes, which mainly affect the media of the artery, as it is crucial to suspect this life-threatening diagnosis in patients at risk. ""Purpose:? To examine the rates of intermediate-term intraocular pressure (IOP) control after trabeculectomy with adjunctive mitomycin C (MMC) and assess for associated complications.