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7, phosphocholine/glycerophosphocholine?=?1.8 and PME/PDE?=?2.3. Considering the relatively short [https://en.wikipedia.org/wiki/CAPNS1 CAPNS1] T2* values of the metabolites in breast tissue at 7?T, the echo spacing can be short without compromising spectral resolution, whilst maximizing the sensitivity. Copyright ? 2013 John Wiley & Sons, Ltd. ""This study aimed to evaluate whether MR metabolic profiling can be used for prediction of long-term survival and monitoring of treatment response in locally advanced breast cancer patients during neoadjuvant chemotherapy (NAC). Methods: High resolution magic angle spinning (HR MAS) MR spectra of pre- and post-treatment biopsies from 33 patients were acquired. Tissue concentrations of choline-containing metabolites (tCho), glycine and taurine were assessed using electronic reference to access in vivo concentration (ERETIC) of the signal and receiver operating characteristic (ROC) curves was used to define their potential to predict patient survival and treatment response. The metabolite profiles obtained by HR MAS spectroscopy were related to long-term survival and treatment response by genetic algorithm partial least squares discriminant analysis (GA PLS-DA). Different pre-treatment MR metabolic profiles characterized by higher levels of tCho and lower levels of lactate were observed in patients with long-term survival (��5?years, survivors) compared to patients who died of cancer recurrence ([http://www.selleckchem.com/products/s-gsk1349572.html Dolutegravir ic50] survival (p?=?0.046) and partial response (p?=?0.014) to NAC. Long-term survival was best predicted by GPC using ROC analyses (sens. 66.7%, spec. 62.5%), while taurine had the best predictive value of treatment response (sens. 72.7%, spec. 63.2%). GA PLS-DA multivariate classification models successfully discriminated between survivors and non-survivors, resulting in 82.7% and 90.2% cross-validation (CV) classification accuracy, pre- and post-treatment, respectively. Classification [http://www.selleckchem.com/products/bmn-673.html Talazoparib in vitro] of treatment response using GA PLS-DA was not successful for this patient cohort. Our results demonstrate that HR MAS MR metabolic profiles consisting of important metabolic characteristics of breast cancer tumors could potentially assist the classification and prediction of long-term survival in locally advanced breast cancer patients, in addition to being used as an adjunct for evaluation of treatment response to NAC. Copyright ? 2011 John Wiley & Sons, Ltd. ""Energy transfer in self-assembled ionic liquids (ILs) and iron oxyhydroxide nanocrystals and the controlled surface chemistry of functionalized nanomaterials for photocatalytic applications are reported. Self-assembled ILs play the role of multifunctional materials in terms of constructing a well-designed nanostructure, controlling the surface chemistry, and triggering the energy transfer of functionalized materials.