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The right ventricular branches arise from the middle segment of the RCA. The number of these branches varies greatly and is inversely proportional to the diameter of such vessels [66]. Acute marginal branches are further arteries arising from the RCA [66]. Additionally, in 14�C15.1% of cases, usually after the acute marginal branch, there follows the posterior right diagonal artery [67,68]. The atrioventricular node artery originates in 90% of cases from the RCA at the level of the crux and is considered as the first inferior septal perforating branch [65]. At the level of the crux, the RCA divides into two terminal branches: the PDA and the posterolateral artery. The PDA gives rise to posterior septal [http://en.wikipedia.org/wiki/Diglyceride diglyceride] branches [66]. In the case of a right-dominant pattern of heart circulation which occurs in approximately 85% of patients, the left circumflex artery has two or three obtuse marginal branches [66]. Additionally, in 25% of cases, the sinoatrial node artery derives from the LCx [66]. At the end of the proximal segment, there arises the left atrial branch [66]. From the LAD, except for septal branches described before, usually three diagonal branches arise [66]. Moreover, short right ventricular branches might be present. This description of the coronary tree shows that the LCx has fewer branches compared with the RCA, and no septal perforators like LAD or [http://www.selleckchem.com/products/GDC-0941.html GDC-941] PDA. As it was mentioned before, branching points and intramyocardial septal perforators are known to generate a number of risk points with a complex disturbed flow. The frequency of branching and SB distribution determines [http://www.selleckchem.com/products/AZD0530.html AZD0530 datasheet] the plaque pattern and explains why the most prevalent location of atherosclerosis is the proximal LAD and why in the RCA the plaques are distributed more evenly. Finally, it also explains why the LCx is relatively protected against atherosclerosis with a predominance for plaque formation in close proximity to the first side branches (obtuse margin). Conclusions Plaque distribution is not uniform. Atherosclerosis occurs more commonly in the LCA than in the RCA but the LCx is less frequently affected. Septal perforators arising from the LAD and RCA cause higher prevalence of atherosclerosis in those two arteries. This effect is intensified by multiple branching points of the RCA and LAD in comparison to the LCx. The architecture of coronary anatomy branching explains the non-uniform distribution of atherosclerotic plaques and prevalence of atherosclerosis in the LAD and RCA in comparison to the LCx. Footnotes Disclosures Authors have no conflicts of interests/financial to disclose.X-linked adrenoleukodystrophy (X-ALD) is caused by a defective transporter protein (ABCDP) in the peroxisomal ��-oxidation, which results in the accumulation of very long-chain fatty acids (VLCFA) in tissues (white matter of the central nervous system, adrenal cortex, testes) and blood.