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These were provided predominantly by mothers (81%), with the remainder being provided by fathers. Summary scores reported by the parents are also presented in Table 2. The validity of the CHO-KLAT2.0 was determined [http://www.selleckchem.com/products/mcc950-sodium-salt.html MCC950 order] in comparison to the PedsQL and Haemo-QoL, using child self-report data from baseline. The Pearson��s correlation between the CHO-KLAT2.0 and the PedsQL was 0.62 (P[http://www.selleckchem.com/products/midostaurin-pkc412.html http://www.selleckchem.com/products/midostaurin-pkc412.html] of the relationship between group classification and CHO-KLAT2.0 scores by using analysis of variance. We found a statistically significant relationship (P = 0.0004), with 27% of the variance in scores being explained by the group classification. Exploratory t tests between groups showed statistically significant differences (P��0.05) between each pair of groups, with the exception of between groups 1 and 2. Responsiveness to change was explored by comparing the summary scores between those who reported a bleed during the 2-week period prior to completing the survey and those who had not. The CHO-KLAT2.0 showed a 12.2-point difference between those with and without a recent bleed (P = 0.0002). Note that while both the other QOL measures also detected differences between those with and without a bleed, these differences were smaller: the PedsQL difference was 8.0 (P = 0.03) and the Haemo-QoL difference was 9.6 (P = 0.01). The ICC between time [http://en.wikipedia.org/wiki/PRDX5 PRDX5] 1 and 2 was computed for 24 boys who had indicated stable disease status between the two time points and who recorded their own answers. On average, the first and second assessments were completed 19 days apart (range = 3�C37 days, median of 17.5 days). The test-retest reliability of the CHO-KLAT2.0 was 0.63 based on two-way random effects absolute agreement. The test-retest concordance for parent-proxy report was analyzed on the basis of data from 26 parents whose first and second assessments were completed an average of 22 days apart (range 6�C40 days, median of 21 days).