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Table?4 Statistical analysis of differences between Ill and Well consumer subsamples Discussion Principal findings and comparison with prior work The objective of this study was to determine the key motivators for individuals to adopt electronic PHRs, through a theoretical behavioural model developed here. Furthermore, as previous research and theoretical reasoning indicated that people with chronic illnesses may be more likely to be favourable to the adoption of PHRs than people who are well,9 in our study we use the model we developed to compare two subsamples drawn in Canada from these two populations in order to assess empirically the possible behavioural differences and their determinants. Our study (table 3 and figure 2) confirms largely the findings of research in information systems according to which [http://en.wikipedia.org/wiki/Raf_kinase TAK-632] perceived usefulness is the key explanation of the [http://www.selleckchem.com/products/iwr-1-endo.html IWR-1 solubility dmso] behavioural intention to use an information technology application.44 Therefore individuals, either chronically ill or well, would use PHRs only if they see the usefulness of these artefacts. This is concordant with findings on other empirical studies on PHRs that showed relative advantage22 or perception of empowerment45 as key motivators of adoption. As expected from previous research,17 the perception of security, privacy and trust in PHRs is a significant motivator for use in both categories of individuals surveyed. Table?3 shows that this factor is second in terms of total effect to Perceived Usefulness only, being significant at p[http://www.selleckchem.com/products/gdc-0068.html Selleckchem Ipatasertib] to medical records online may outweigh privacy risk perceptions.46 Study results confirm that information seeking and personal IT innovativeness are motivators of PHR use for both categories of potential users while exerting their influence through perceived usefulness (table 3 and figure 2). However, the total effect of personal IT innovativeness over adoption intention is not significant for the Ill subsample, but it is for the Well subsample (table 3). As hypothesised, computer anxiety is the only deterrent on PHR adoption in the theoretical model proposed by this study. It has a negative total influence significant at p