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The secondary endpoint was sustained remission (CDAI [http://www.selleckchem.com/products/PD-0332991.html Palbociclib manufacturer] in adverse events associated with each arm: 92% in the dual therapy group and 100% in the infliximab plus placebo group experienced side effects. The most common adverse events were headache, exacerbation of CD, nausea and nasopharyngitis. The mean decrease in the CDAI was 37.7 points in the dual therapy arm compared with an increase by 3.5 points in the monotherapy group (p = 0.08). A Cochrane review of [http://www.selleckchem.com/products/Everolimus(RAD001).html http://www.selleckchem.com/products/Everolimus(RAD001).html] natalizumab therapy including the above four trials concluded its effectiveness for induction of clinical response and remission in patients with moderate to severe CD [MacDonald and MacDonald, 2007]. The number needed to treat (NNT) to gain response [http://en.wikipedia.org/wiki/Cofactor_(biochemistry) Cofactor] with a single infusion was 17; if two infusions were given, the NNT decreased to 10. The NNT for response and remission following three infusions was 12 and 10, respectively, at 12 weeks. Another systematic review showed that failure to achieve remission occurred in 65.4% of patients receiving natalizumab at weeks 2 to 12 compared with 77.3% of patients receiving placebo [Ford et al. 2011]. Moreover, both studies found a similar incidence of side effects with natalizumab and placebo therapy. Another report found that 69% of patients with extensive ileocolonic disease who had failed prior conventional immunosuppressants and at least two anti-TNF agents exhibited at least partial response (a decrease in HBI by ?3 points) to natalizumab [Ananthakrishnan et al. 2012]. Juillerat and colleagues noted a 46% clinical response (HBI decrease ?3 points) and a 56% cumulative probability of achieving remission (HBI