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The loess curves for the individual MBPI scales (Figure S1) showed that the clearest relationship between pain and function with pregabalin was for Sleep, with an almost linear relationship [http://www.selleckchem.com/products/Verteporfin(Visudyne).html selleck screening library] across the range of percent change in pain. Domains related to mental components (Mood, Normal Relations, and Social Activities) appeared to have a more complex relationship relative to domains related to physical activity, although the overall trends still suggested greater function with increased pain relief. For the combined results of both studies, the data ellipses of the MOS-SS showed that pregabalin resulted in a shift from placebo toward greater improvements in sleep at higher levels of pain relief (Figure 2A). The loess curve (Figure 2B) showed that the relationship between pain and MOS-SS appeared to be almost linear for both pregabalin and placebo, but the magnitude of the improved [http://www.selleckchem.com/products/Vandetanib.html Vandetanib order] sleep was greater with pregabalin relative to placebo for pain relief ��30%. While the data ellipses of the patient diary sleep NRS (Figure 2C) showed a trend similar to the MOS-SS, the loess curves of placebo and pregabalin almost overlap, with both demonstrating an almost linear relationship between pain relief and improved sleep (Figure 2D). Figure 2 Scatter plots of the relationship between pain reduction and sleep assessed using the MOS-SS (A and B) and the patient daily diary using an 11-point sleep interference Numeric Rating Scale (C and D). Data ellipses of the changes in HADS scores showed that relative to placebo, pregabalin results shifted toward the right, indicating an improvement in pain, but there was no shift upward in the direction of improvements in anxiety or depression (Figure 3A and C). Loess curves were flat for both placebo and pregabalin, further indicating a lack of relationship between pain relief and improvement in anxiety or depression (Figure 3B and D). [https://en.wikipedia.org/wiki/Itraconazole Itraconazole] Figure 3 Scatter plots of the relationship of pain reduction with changes in anxiety (A and B) and depression (C and D) measured using the HADS. Additionally, when the relationship between pain and function was explored regarding pregabalin treatment using linear trend analysis, significance (P