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Two subjects who transitioned into the FM+CWP+ group at follow-up (one FM?CWP? �� FM+CWP+, one FM?CWP+ �� FM+CWP+) reported using physical treatments for pain in the 3 months prior to [https://en.wikipedia.org/wiki/Itraconazole Itraconazole] the baseline assessment. Transitions out of FM+CWP+ The 20 subjects who no longer met the study definition and transitioned out of the FM+CWP+ group at follow-up differed from subjects who remained in the FM+CWP+ group on some baseline measures. Specifically, subjects who transitioned out of the FM+CWP+ group had been diagnosed with FM more recently (mean [SD] number of months since diagnosis; FM+CWP+ �� FM?CWP?: 2.4 [7.52], FM+CWP+ �� FM?CWP+: 15.6 [46.81] vs FM+CWP+ �� FM+CWP+: 64.0 [92.30]; Table S2) and reported higher baseline SF-12v2 physical function scores (FM+CWP+ �� FM?CWP?: 40.9 [30.15], FM+CWP+ �� FM?CWP+: 47.2 [34.11] vs FM+CWP+ �� FM+CWP+: 29.9 [31.41]; Table S2) and higher baseline SF-12v2 bodily pain scores/less bodily pain (FM+CWP+ �� FM?CWP?: 52.3 [20.78], FM+CWP+ �� FM?CWP+: 50.0 [27.95] vs FM+CWP+ �� FM+CWP+: 36.6 [23.82]; Table S2). For other clinical outcomes and PROs, less marked differences were observed among those who transitioned out of the FM+CWP+ group at follow-up and those who remained in the FM+CWP+ group (Table S2). Thirty percent of subjects (six out of 20) who transitioned out of the FM+CWP+ group at follow-up experienced a reduction in the number of positive tender points (��11 to [http://www.selleckchem.com/products/Verteporfin(Visudyne).html Verteporfin research buy] subjects were CWP? at follow-up; eight of these subjects, though [http://www.selleckchem.com/products/Vandetanib.html selleck compound] the physician confirmed FM at both assessments, did not meet the FM study definition because they screened negative for CWP at follow-up. Among the 20 subjects who transitioned out of the FM+CWP+ group at follow-up, the following comorbidities were reported at baseline: anxiety (n=5), arthritis (n=8), chronic fatigue syndrome (n=3), depressive symptoms (n=9), diabetes (n=6), headache/migraine (n=4), hypertension (n=8), IBS (n=3), lower back pain (n=10), neuropathies (n=1), RLS (n=2), sleep apnea (n=5), and TMJD (n=3). Sixteen of the 20 subjects who transitioned out of the FM+CWP+ group reported changes in the presence of 12 different comorbidities from the baseline to the follow-up assessment. These changes included new comorbidities (ie, chronic fatigue syndrome [n=1], headache/migraine [n=1], hypertension [n=1], lower back pain [n=4], neuropathies [n=2], and sleep apnea [n=1]) as well as comorbidities no longer reported at follow-up (ie, anxiety [n=1], arthritis [n=1], depressive symptoms [n=1], diabetes [n=2], headache/migraine [n=1], hypertension [n=3], lower back pain [n=3], RLS [n=2], sleep apnea [n=1], and TMJD [n=1]).