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005). Fluorescence microscopic [http://en.wikipedia.org/wiki/DDR1 DDR1] images show the capaiblity of the functionalized constructs in NIR imaging of HER2 overexpression. The functionalized nano-constructs are also capable of inducing a significantly greater increase in photothermal destruction of SKOV3 cells than free ICG and non-functionalized constructs (P?[http://www.selleckchem.com/products/ABT-888.html Veliparib price] imaging, and phototherapy of small ovarian cancer nodules. Lasers Surg. Med. 46:582�C592, 2014. ? 2014 Wiley Periodicals, Inc. Ovarian cancer is the deadliest gynecological cancer in women [1]. Only about 20% of ovarian cancers are diagnosed when the disease is confined to the ovaries [2] (classified as stage I [3]). Once the disease spreads beyond the ovaries, and extends into the pelvis (below the pelvic brim) (stage II), the peritoneum outside the pelvis and/or into the retroperitoneal lymph nodes (stage III), or metastasizes distantly to hepatic and/or splenic parenchymal or the extra-abdominal organs (stage IV), the survival rate is greatly diminished [2], with 5-year survival rates less than 20% [4]. Treatment of ovarian cancer is based on cytoreductive surgery, with the goal of reducing the burden of the cancer to none or minimal residual tumor deposits, followed commonly by administration of standard chemotherapeutic combination of carboplatin and paclitaxel [5-7]. However, most patients suffer from recurrence, and are chemoresistant [5, 7]. The degree of success [http://www.selleckchem.com/products/Methazolastone.html Temozolomide] in cytoreductive surgery is an important prognostic factor, with improved survival associated with complete resection of all visible cancer [8-10]. Yet, a great challenge during cytoreduction remains the detection of small (diameter