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In addition, abnormalities in nondominant frontal, temporal, and parietal lobes, areas known to be affected by schizophrenia, have also been related with CS [3]. Some authors considered nihilist delusions as an extreme [https://en.wikipedia.org/wiki/Oxyclozanide oxyclozanide] manifestation of the topic of death [10]. However, considering the cooccurrence of Cotard and Capgras syndromes (the latter is the most common misidentification syndrome) [5, 7, 12, 13], it could be conceptualized that both monothematic and bizarre delusions are related with loss of the sense of the inner self that is core and typical of schizophrenia. Alternately, CS can be conceptualized as a dysfunction of egocentric mind-representing system (as asomatognosia is conceptualized as damage of the egocentric body-representing system) [14]. This phenomenon can be mediated by dysfunction of insular cortex, an area that plays a central role in the conscious awareness of internal sensations and that is known to be affected by stress [15, 16]. Although CS is not a psychiatric diagnosis but a feature of several neurological and psychiatric conditions, psychiatrists should be aware of this uncommon psychotic phenomenon to prompt diagnosing, describing, and treating according to the best evidence. 4. Conclusion Despite not being considered in actual classifications, Cotard syndrome is still relevant and clinical recognition is critical to diagnosing and treating this condition in psychiatric patients. Conflict of Interests The authors declare [http://www.selleckchem.com/products/Decitabine.html Decitabine purchase] that there is no conflict of interests regarding the publication of this paper.""Valproic acid (VPA) is a classic antiepileptic drug (AED) and has been a major pharmaceutical tool in the management of a range of psychiatric and neurological diseases since the 1960s [1]. VPA is currently approved in the US for the treatment of several types of epilepsy, bipolar disorder, and migraine prophylaxis. The maximum recommended doses for epilepsy or bipolar disorder are 60?mg/kg/day [2]. It is rare to see patients taking >4000?mg/day. Moreover, therapeutic drug monitoring (TDM) is frequently [http://www.selleckchem.com/products/CP-673451.html PDGFR inhibitor] used to establish and track VPA doses. Neurologists frequently use a therapeutic range of 50�C100?��g/mL for epilepsy [3]. The therapeutic range in bipolar disorder is not very well established but some reviews recommend up to 125?��g/mL for mania [2]. In spite of decades of use, VPA metabolism is not completely understood [3�C8]. VPA primarily undergoes hepatic metabolism, while