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MRSt used point-resolved spectroscopy (no water suppression; TR?=?1370?ms; TE?=?288?ms; 1.5?��?1.5?��?1.5?cm3 Thal and 1.1?��?1.3?��?1.4?cm3 [https://en.wikipedia.org/wiki/Cilengitide Cilengitide] WM voxels). Time domain data were phase and frequency corrected before summation and motion-corrupted data were excluded from further analysis using simple criteria [preprocessing?+?quality assurance (QA)]. Two published water temperature-dependence calibrations [both using cerebral creatine (Cr), choline (Cho) and N-acetylaspartate (Naa) as independent reference peaks] were compared. The temperature measurements derived from Cr, Cho and Naa were combined to give a single amplitude-weighted combination temperature (TAWC). WM [http://www.selleckchem.com/products/Everolimus(RAD001).html Everolimus in vivo] and Thal TAWC correlated linearly with Trectal (Thal slope, 0.82?��?0.04, R2?=?0.85, p?[http://www.selleckchem.com/products/PD-0332991.html http://www.selleckchem.com/products/PD-0332991.html] used both capacitive decoupling and the partial geometric overlapping of adjacent coil elements. The decoupling scheme allowed coil elements to be arrayed along all three Cartesian axes; this facilitated shimming of the transmit field, B, and parallel imaging acceleration along the longitudinal direction in addition to the standard transverse directions. Each channel was independently controlled during imaging using a 16-channel console and a 16?��?1-kW RF amplifier�Cmatrix. The mean isolation between all combinations of coil elements was 18?��?7?dB. After B shimming, the standard deviation of the transmit field uniformity was 11% in an axial plane and 32% over the entire brain superior to the mid-cerebellum. Transmit uniformity was sufficient to acquire fast spin echo images of this region of the brain with a single B shim solution. Signal-to-noise ratio (SNR) maps showed higher SNR in the periphery vs center of the brain, and higher SNR in the occipital and temporal lobes vs the frontal lobe. Parallel imaging acceleration in a rostral�Ccaudal oblique plane was demonstrated.