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""Aim: Settling (embedment relaxation), which is the main cause for screw loosening, is developed by microroughness between implant and abutment metal surface. The objective of this study was to evaluate and compare the relationship between the level of applied torque and the settling of abutments into implants in external and internal implant�Cabutment connection. Material and methods: Five different implant�Cabutment connections were used (Ext, External butt joint+two-piece abutment; Int-H2, Internal hexagon+two-piece abutment; Int-H1, Internal hexagon+one-piece [http://www.selleckchem.com/products/incb28060.html find more] abutment; Int-O2, Internal octagon+two-piece abutment; Int-O1, Internal octagon+one-piece abutment). All abutments of each group were assembled and tightened with corresponding implants by a digital torque gauge. The total [http://en.wikipedia.org/wiki/Isotretinoin Isotretinoin] lengths of implant�Cabutment samples were measured at each torque (5, 10, 30?N?cm and repeated 30?N?cm with 10-min interval) by an electronic digital micrometer. The settling values were calculated by changes between the total lengths of implant�Cabutment samples. Results: All groups developed settling with repeated tightening. The Int-H2 group showed markedly higher settling for all instances of tightening torque and the Ext group was the lowest. Statistically significant differences were found in settling values between the groups and statistically significant increases were observed within each group at different tightening torques (P[http://www.selleckchem.com/products/gdc-0068.html GDC-0068 cell line] of age and with a need for a single tooth replacement were included. All patients presented with a recipient implant site demonstrating a lingual�Cbuccal bone height discrepancy of 2.0�C5.0?mm and with a neighboring tooth on its mesial aspect. Implant placement (OsseoSpeed? Profile implants; Astra Tech AB, M?lndal, Sweden) was performed using a non-submerged installation procedure. The implants were placed in such a way that the sloped part of the device was located at the buccal and most apical position of the osteotomy preparation.