Net64tax: Створена сторінка: An effect of high dietary phosphorus on renal disease progression in animals cannot be extrapolated to humans, and unfortunately, there is a scarcity of clinica...

2016-12-24T19:05:15Z

Створена сторінка: An effect of high dietary phosphorus on renal disease progression in animals cannot be extrapolated to humans, and unfortunately, there is a scarcity of clinica...

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An effect of high dietary phosphorus on renal disease progression in animals cannot be extrapolated to humans, and unfortunately, there is a scarcity of clinical data on this subject. A few clinical studies, however, have looked at the potential association between serum phosphate levels and the rate of progression of kidney disease in CKD patients (Table 2). O'Seaghdha et al.[10] separated serum phosphate in quartiles in 2269 healthy subjects from the Framingham Heart Study and demonstrated that the odds ratio of developing CKD is much higher in healthy subjects [http://www.selleckchem.com/products/nutlin-3a.html Nutlin-3a cell line] with a serum phosphate >4 mg/dL, even after adjusting for age, gender, body mass index, blood pressure, smoking, diabetes mellitus, and cholesterol. The same authors then divided serum phosphate from 13,372 participants in the National Health [https://en.wikipedia.org/wiki/Oxymatrine Oxymatrine] and Nutrition Examination Survey (NHANES) III into those below and above 4 mg/dL and demonstrated that the relative risk of developing end-stage renal disease (ESRD) is much higher in those subjects with a serum phosphate ��4 mg/dL, even after multiple variable adjustments. Furthermore, Schwarz et al.[11] analyzed historical data in a group of 985 U.S. veterans with different degrees of CKD and found that those patients with higher serum phosphate had a much higher likelihood of developing ESRD compared to those with a serum phosphate [http://www.selleckchem.com/products/Pomalidomide(CC-4047).html Pomalidomide ic50] et al. in another group of 448 CKD patients in the Netherlands.[14] Two new studies have been published addressing a possible association between serum phosphate and progression of renal disease (Table 1).[25, 26] Interestingly, one of the studies[25] shows an association, whereas the other does not.[26] The above data demonstrate that high serum phosphate indeed is associated with worse outcome in CKD/ESRD patients, both as measured by mortality and progression of renal disease. These studies, however, are observational in design and therefore cannot be used to define cause and effect.

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Net64tax: Створена сторінка: An effect of high dietary phosphorus on renal disease progression in animals cannot be extrapolated to humans, and unfortunately, there is a scarcity of clinica...