Cell0linda: Створена сторінка: For assessment of genotoxicity, mutagenicity, and protective effects, all groups were compared using one-way ANOVA and Tukey's test (p?[http://en.wikipedia.org/...

2017-04-17T17:25:39Z

Створена сторінка: For assessment of genotoxicity, mutagenicity, and protective effects, all groups were compared using one-way ANOVA and Tukey's test (p?[http://en.wikipedia.org/...

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For assessment of genotoxicity, mutagenicity, and protective effects, all groups were compared using one-way ANOVA and Tukey's test (p?[http://en.wikipedia.org/wiki/FKBPL FKBPL] C)]?��?100, where A is the group treated with cDDP (positive control), B is the group treated with different doses of CLb plus cDDP and C represents the MO group treated with mineral oil (control group). None of these animals died during the 15 days of treatment, and no differences were observed in the body weight of treated males and females compared to the control group (MO). The same was observed for the organ weight/body weight ratio for each animal, suggesting that neither CLb nor cDDP have toxic effects on the liver or the kidney at the doses evaluated (Table 1). At T0, 4?h after the first treatment, all groups showed the same standard of DNA migration, with no statistical differences between the groups (p?>?0.05). At T1, 4?h after the injection of saline or cDDP, cDDP treatment decreased DNA migration, and only the highest dose of CLb was able to maintain DNA migration at control (MO [http://www.selleckchem.com/products/gsk1120212-jtp-74057.html http://www.selleckchem.com/products/gsk1120212-jtp-74057.html] group) levels. Positive control group (MMS) included to certified the comet assay conditions showed a significant increase in %DNA in tail (p?[http://www.selleckchem.com/products/AZD2281(Olaparib).html learn more] treatment with MO (2.38?��?0.92). We also found that the number of micronuclei in peripheral blood induced by CLb (1.88?��?1.13 for 0.2?mg/kg b.w. CLb and 2.00?��?0.93 for 0.5?mg/kg b.w. CLb) is in the same range as that of the MO group (2.43?��?0.56), demonstrating that CLb has no effects on these genotoxic endpoints at these doses, in acute and subacute treatments (T1 and T2). On the other hand, administration of cDDP resulted in a significant increase of micronuclei, around 7�C8 times, in both cell types (16.00?��?2.0 for MNRET in T2 and 14.25?��?2.71 for MNPCE) compared to the MO group (data above) (p?

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Cell0linda: Створена сторінка: For assessment of genotoxicity, mutagenicity, and protective effects, all groups were compared using one-way ANOVA and Tukey's test (p?[http://en.wikipedia.org/...