Net64tax: Створена сторінка: ( Supplemental Table?1). Fig.?1 shows the distribution of VLDL-C values for PDHS participants with circulating TG values above and below 150?mg/dl, a clinically...

2017-05-11T07:43:36Z

Створена сторінка: ( Supplemental Table?1). Fig.?1 shows the distribution of VLDL-C values for PDHS participants with circulating TG values above and below 150?mg/dl, a clinically...

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( Supplemental Table?1). Fig.?1 shows the distribution of VLDL-C values for PDHS participants with circulating TG values above and below 150?mg/dl, a clinically meaningful cut-point [16]. Notably, there was substantial overlap in VLDL-C in these two groups with non-overlapping TG values suggesting that VLDL-C provides information distinct from total TGs regarding TGRL metabolism. While there was no significant race interaction for VLDL-C association with CAC, there tended to be a gender difference, so results are presented stratified by gender [http://www.selleckchem.com/products/ly2109761.html find more] as well as for the full sample. VLDL-C levels were positively associated with increasing CAC after adjusting for age, gender, and race, Framingham risk scores, exercise, HbA1c, medication and alcohol use, (Tobit Ratio (TR) 0.38 CI 0.12�C0.65, P?=?0.005) and even after further adjusting for duration of diabetes, BMI, and CRP (TR 0.38 CI 0.12�C0.65, P?=?0.005). Furthermore, addition of plasma apoB levels did not attenuate association of VLDL-C with CAC (TR 0.31 CI 0.03�C0.58, p?=?0.030) ( Table?2). Although the same trends were evident in both genders, there was approximately 3-fold stronger association of VLDL-C with CAC in women than in men (gender interaction P?=?0.034 in Model 1 and P?=?0.048 in Model 4), with statistically significant effects observed in women but not in men ( Table?2). These finding persisted in subgroup analysis in patients not on lipid lowering [http://www.selleckchem.com/products/epz-5676.html EPZ5676 ic50] therapy. ( Supplemental Table?2) VLDL-C may relate to CAC and CVD independent of TG levels because cholesterol-rich VLDL particles may impart greater atherogenic risk than total TGs which are distributed across all lipoprotein particles, not just VLDL. Because TG and VLDL-C values were highly correlated, however, their inclusion in models together can lead to excess colinearity and potential spurious findings. Therefore, we compared plasma VLDL-C and TG association with CAC in non-nested models using AIC and BIC scores and found that both AIC and BIC scores were slightly but consistently lower for VLDL-C (e.g., in fully adjusted Model 4; AIC 7263.65, BIC 7402.11) than TG (AIC 7263.94, BIC 7402.40). This suggests that VLDL-C performs better than TG in predicting CAC scores when all other confounders and covariates are held equal. Furthermore, we stratified PDHS participants into [http://en.wikipedia.org/wiki/MAPK MAPK] those with TG values below and above 150?mg/dl, a cut-point used in clinical practice. [16] In these stratified analyses, VLDL-C had stronger association with CAC in individuals with TGs >150?mg/dl (TR 0.80, P?=?0.01) than those with TGs

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Net64tax: Створена сторінка: ( Supplemental Table?1). Fig.?1 shows the distribution of VLDL-C values for PDHS participants with circulating TG values above and below 150?mg/dl, a clinically...