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(Створена сторінка: The age of the patients at the onset of metachronous cancer or in the TNM stage according to the sixth edition of the American Joint Committee on Cancer (AJCC),...)
 
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The age of the patients at the onset of metachronous cancer or in the TNM stage according to the sixth edition of the American Joint Committee on Cancer (AJCC), and the presence of factors that could mediate effects on survival rate were examined retrospectively. Evaluation of the interval from the first pathologic diagnosis of breast cancer to the development of a second primary cancer, clinical characteristics, and survival rate after diagnosis of a second cancer was based on medical records. The control population was extracted from data provided by the Korean Central Cancer Registry and the National Cancer Center operated by the Ministry of Health and Welfare. 1. Statistical analysis The yearly incidence (per 100,000) of the various malignancies in both the control and breast cancer were compared. The ratio of these two values and 95% confidence intervals indicated the RR coefficient of having [https://en.wikipedia.org/wiki/Fossariinae Fossariinae] cancer. The Kaplan-Meier method was used for generation of overall survival curves. The survival curve for patients with metachronous double primary cancer was calculated from the date of diagnosis of the second cancer. Analyses were conducted using SPSS ver. 18.0 (SPSS Inc., Chicago, IL). Results Among 2,657 patients with breast cancer, 108 (4.1%) were diagnosed with metachronous double primary cancer. In a comparison of the sex distribution [http://www.selleckchem.com/screening/pi3k-signaling-inhibitor-library.html PI3K Inhibitor Library cell line] of the patients, double primary cancer occurred more frequently in males but was not statistically different. Double primary cancer occurred in one of 15 males (6.7%) and 107 of 2,642 female (4.2%) patients (p=0.464). As shown in Table 1, age distribution between groups did not differ (p=0.053). The most common age group included patients aged 40 to 50, and the most common metachronous double primary cancer was thyroid cancer, followed by stomach, endometrium, cervix, and lung cancers. Table 1. Sex and age distribution at the time of diagnosis of breast cancer with or without second primary cancer Table 2 shows the median age distribution of patients with metachronous double primary cancer. A significant difference was observed among the types of metachronous double primary cancers (p [http://www.selleckchem.com/products/Sunitinib-Malate-(Sutent).html selleckchem] had the oldest median age of 73.8 years, while nasopharyngeal cancer had the youngest age of 39.5 years. Table 2. Cancer type and mean age distribution of metachronous double primary cancer in breast cancer patients Table 3 shows the yearly diagnostic period of metachronous double primary cancer and does not indicate any notable difference in incidence from year to year. The mean diagnostic period was 58.4��41.2 months, and no significant differences were observed among cancer types (p=0.157). Acute leukemia, thyroid, colorectal, and biliary cancers were diagnosed earlier than other cancers (Table 4). Table 3.
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Поточна версія на 13:09, 30 грудня 2016

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