Відмінності між версіями «532 lean controls (French Caucasians) 154 Swedish households (732 subjects) 1279 Japanese 1390 Dutch Caucasians 1390 Dutch»

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532 lean controls (French Caucasians) 154 Swedish households (732 subjects) 1279 Japanese 1390 Dutch JSH-23 site Caucasians 1390 Dutch Caucasians 1802 Spanish Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1502 Japanese individuals with T2DM 1740 controls 1770 Austrian Caucasians 1770 Austrian Caucasians 1502 Japanese individuals with T2DM 1740 controls 1502 Japanese sufferers with T2DM 1740 controls 3501 Pima Indians 3003 Native Americans 8598 Dutch Caucasians 3501 Pima Indians 3003 Native Americans 6504 North Americans 3501 Pima Indians 3003 Native Americans References [77] [94] [96] [96] [97] [98] [98] [98] [98] [105] [98] [98] [105] [105] [79] [92] [79] [79] [79] [79] [79]No association with BMI and weight C C T G G G Decreased mortality in obese/overweight people Superior glucose tolerance in guys Greater BMI in males Reduce intima-media thickness in men Greater intima-media thickness in girls Lower intima-media thickness in males Higher intima-media thickness in ladies Associated with diabetic nephropathy Reduce intima-media thickness in guys Greater intima-media thickness in females Related with diabetic nephropathy Connected with diabetic nephropathyrs2236319 (A/G)G ASIRT1 rs10823108 (G/A)A A G T rs4746720 (T/C)No association with BMI and fat content material rs497849 (G/A) G T rs10509291 (T/A) T Increased mortality in diabetic individuals (in a haplotype with rs1467568G/rs7895833A) Associated with type 2 diabetes Not related with variety 2 diabetesNo association with BMI and fat content rs7896005 (G/A) G G Associated with sort 2 diabetes Not JNJ-7706621 linked with kind two diabetesInt. 2016, 17,16 ofTable 1. Cont.Gene Polymorphism ?rs3758391 (C/T) Allele/Genotype No association with BMI and fat content material C Protects from kind 2 diabetes Association Population 6504 North Americans 519 Mexican patients with T2DM 389 Mexican individuals with MS 547 Mexican controls 1502 Japanese sufferers with T2DM 1740 controls 1356 North Americans 1356 North Americans 1356 North Americans title= journal.pcbi.1005422 1356 North Americans 1356 North Americans 1356 North Americans 1356 North Americans 1356 North Americans 1356 North Americans References [79] [104]SIRTrs3818292 (A/G) SIRT2 rs4802998 (A/G) rs12363280 (C/G) SIRT3 rs4980329 (T/C) rs3825075 (T/C) SIRT5 rs4712032 (A/G) rs12216101 (G /T) SIRT6 rs107251 (C/T) rs3760905 (G/T)A G G C T TT G G T TAssociated with diabetic nephropathy Larger intima-media thickness Larger grey scale median indicator of plaque morphology in addition to a predictor of stroke Reduced intima media thickness Greater grey scale median--an indicator of plaque morphology plus a predictor of stroke Lower intima media thickness in ladies Elevated variety of carotid plaques Enhanced variety of carotid plaques Improved number of carotid plaques Elevated number of carotid plaques[105] [100] [99] [100] [99] [100] [99] [99] [99,101] [99,101]BMI--Body mass index; CVD--cardiovascular ailments; LDL-C--low density lipoproteins cholesterol; MS--Metabolic syndrome; T2DM--Type two diabetes mellitus; TC--Total cholesterol.Int. J. Mol. Sci. 2016, 17,17 of6. Sirtuins as Targets for Obesity Remedy Given their function inside the regulation of lipid and glucose metabolism, adipogenesis and appetite handle SIRTs constitute promising targets for novel therapies of obesity and associated metabolic problems. Having said that, the discovery of a single compound that could be in a position to activate some SIRTs isoforms and inhibit other folks is still a challenge.532 lean controls (French Caucasians) 154 Swedish households (732 subjects) 1279 Japanese 1390 Dutch Caucasians 1390 Dutch Caucasians 1802 Spanish Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1770 Austrian Caucasians 1502 Japanese individuals with T2DM 1740 controls 1770 Austrian Caucasians 1770 Austrian Caucasians 1502 Japanese individuals with T2DM 1740 controls 1502 Japanese individuals with T2DM 1740 controls 3501 Pima Indians 3003 Native Americans 8598 Dutch Caucasians 3501 Pima Indians 3003 Native Americans 6504 North Americans 3501 Pima Indians 3003 Native Americans References [77] [94] [96] [96] [97] [98] [98] [98] [98] [105] [98] [98] [105] [105] [79] [92] [79] [79] [79] [79] [79]No association with BMI and weight C C T G G G Reduced mortality in obese/overweight individuals Far better glucose tolerance in guys Higher BMI in men Reduced intima-media thickness in males Greater intima-media thickness in ladies Decrease intima-media thickness in men Higher intima-media thickness in girls Related with diabetic nephropathy Reduce intima-media thickness in guys Greater intima-media thickness in females Linked with diabetic nephropathy Connected with diabetic nephropathyrs2236319 (A/G)G ASIRT1 rs10823108 (G/A)A A G T rs4746720 (T/C)No association with BMI and fat content rs497849 (G/A) G T rs10509291 (T/A) T Improved mortality in diabetic patients (in a haplotype with rs1467568G/rs7895833A) Connected with form 2 diabetes Not connected with form two diabetesNo association with BMI and fat content rs7896005 (G/A) G G Related with form 2 diabetes Not connected with sort two diabetesInt.