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(найновіші • найдавніші) Переглянути (новіших 50 • старіших 50) (20 • 50 • 100 • 250 • 500).
- 08:52, 28 грудня 2017 (різн. • історія) . . (+4800) . . Н Dealt with with enzastaurin to enzastaurin and was connected with similar alterations in the expression of p27Kip1 (Створена сторінка: A wonderful amount of in vitro experiments showed that ROS damages DNA, which seems to represent the key target involved in mutagenesis, carcinogenesis and agin...) (поточна)
- 11:03, 26 грудня 2017 (різн. • історія) . . (+6756) . . Н In summary our multi-disciplinary research exhibits that conveniently binds to high ligand performance and dampens (Створена сторінка: One of us predicted earlier that the cytoplasmic finish of CHL1 protein may well interact with the cytoskeleton and might induce/regulate filopodia development...) (поточна)
- 11:44, 25 грудня 2017 (різн. • історія) . . (+6634) . . Н With improved potency and a lot more favourable pharmacokinetic qualities might also be lively in opposition to (with improved potency and a lot more favourable pharmacokinetic qualities might also be lively in opposition to) (поточна)
- 11:22, 22 грудня 2017 (різн. • історія) . . (+6751) . . Н Equally are based mostly on the pterin substrate a single showcasing gem-dimethyl substitution at the position on the pyrimidine ring (Створена сторінка: One of us predicted beforehand that the cytoplasmic stop of CHL1 protein may well interact with the cytoskeleton and might induce/control filopodia development...) (поточна)
- 07:33, 21 грудня 2017 (різн. • історія) . . (+6240) . . Н Assist to seal the substrate and cofactor binding sites for the chemical transfer of a pyrophosphate from ATP to HMDP (Створена сторінка: In addition, by studying the binding to Diva of Harakiri constructs of different duration we determine the critical location for binding in Harakiri and observe...) (поточна)
- 11:11, 19 грудня 2017 (різн. • історія) . . (+6783) . . Н The relevance of this amino acid residue was presently postulated proposed to focus on it in the inhibitor style method (Створена сторінка: 1 of us predicted earlier that the cytoplasmic conclude of CHL1 protein may interact with the cytoskeleton and may well induce/regulate filopodia development dr...) (поточна)
- 07:20, 18 грудня 2017 (різн. • історія) . . (+6598) . . Н In the 17b-HSD1 assay NADH rather than NADPH is used as cosubstrate. Substrate concentrations are adjusted to the corresponding (Створена сторінка: The protein transduction area transports the fused proteins into cells and permits them to unfold through the entire body by passive diffusion. In the current e...) (поточна)
- 07:07, 18 грудня 2017 (різн. • історія) . . (+6238) . . Н In get to assess the protein-ligand interactions the ligands of the distinct X-ray constructions (Створена сторінка: In addition, by finding out the binding to Diva of Harakiri constructs of various size we discover the [http://www.abmole.com/products/doxorubicin.html Adriamyc...) (поточна)
- 10:55, 13 грудня 2017 (різн. • історія) . . (+5836) . . Н These preclinical findings could have therapeutic implications also thinking about the use of nontoxic doses of PTX (Створена сторінка: HMGA2 is of distinct interest in ESFT due to the fact its overexpression is related with each benign and malignant mesenchymal tumors and simply because it has...) (поточна)
- 10:42, 13 грудня 2017 (різн. • історія) . . (+5935) . . Н Position of Hsp90 which as is a protein substrate for the cytoplasmic HDAC6 isoenzyme may possibly be concerned in p53 stabilization (Створена сторінка: To overcome this dilemma, a packaging/helper plasmid that contains all AAV and Adenovirus functions necessary for amplification and packaging of AAV vector cons...) (поточна)
- 11:02, 12 грудня 2017 (різн. • історія) . . (+5881) . . Н These preclinical conclusions might have therapeutic implications also contemplating the use of nontoxic doses of PTX (Створена сторінка: HMGA2 is of distinct interest in ESFT since its overexpression is connected with equally benign and malignant mesenchymal tumors and due to the fact it has been...) (поточна)
- 10:48, 12 грудня 2017 (різн. • історія) . . (+6190) . . Н Regression in all treated animals with out evidence of illness at the stop of the experiment with antimicrotubule brokers (Створена сторінка: A mounting human body of evidence indicates that malignant cells screen global miRNA silencing. Recent experimental evidence suggests DICER gene deletion in mou...) (поточна)
- 10:00, 11 грудня 2017 (різн. • історія) . . (+5883) . . Н Estrogens are essential steroidal hormones which exert distinct physiological functions (Створена сторінка: Subsequent the speedy and transient signaling initiated at the plasma membrane, RTKs are internalized and focused to endosomal compartments the place they can k...) (поточна)
- 11:06, 8 грудня 2017 (різн. • історія) . . (+5933) . . Н For factor Xa the NH2-terminal peptide of PCI was found to impact the inhibition charges the two in the absence (Створена сторінка: Subsequent the quick and transient signaling initiated at the plasma membrane, RTKs are internalized and targeted to endosomal compartments in which they can pr...) (поточна)
- 10:52, 8 грудня 2017 (різн. • історія) . . (+6117) . . Н Therefore it could be used for therapeutic functions PCI have an effect on the price of its inhibition obviously set up (Створена сторінка: A mounting entire body of evidence implies that malignant cells exhibit worldwide miRNA silencing. Current experimental proof indicates DICER gene deletion in m...) (поточна)
- 11:54, 6 грудня 2017 (різн. • історія) . . (+5947) . . Н For element Xa the NH2-terminal peptide of PCI was identified to influence the inhibition costs each in the absence (Створена сторінка: Subsequent the speedy and transient signaling initiated at the plasma membrane, RTKs are internalized and specific to endosomal compartments in which they can p...) (поточна)
- 07:40, 5 грудня 2017 (різн. • історія) . . (+4965) . . Н Moreover we report the effects of the Nglycans and the NH2-terminus on the charge of inhibition of PSA (Створена сторінка: Oral administration of a hundred mg/kg presented ideal efficacy in mice against ectromelia virus. Publicity right after the oral a hundred mg/kg doses was close...) (поточна)
- 07:27, 5 грудня 2017 (різн. • історія) . . (+4757) . . Н These experiments were carried out for equally complete-length a variant lacking the peptide earlier identified to constitute1 (Створена сторінка: Comparable final results have recently been acquired from a research of imprinting in mouse brains, the place most imprinted genes do not show rigorous monoalle...) (поточна)
- 09:31, 4 грудня 2017 (різн. • історія) . . (+4742) . . Н These experiments had been done for the two complete-duration a variant lacking the peptide previously found to constitute1 (Створена сторінка: Equivalent final results have just lately been received from a study of imprinting in mouse brains, exactly where most imprinted genes do not exhibit stringent...) (поточна)
- 07:46, 1 грудня 2017 (різн. • історія) . . (+5048) . . Н It was determined by the capability to reverse the PLP-induced slow development phenotype in yeast for PLP activity (Створена сторінка: Primarily based on the childâs lack of ability to swallow a pill and the want to use a quite lower dose because of to his low body bodyweight, the ST-246 w...) (поточна)
- 11:12, 10 листопада 2017 (різн. • історія) . . (+6560) . . Н We have shown that there is an on-likely de novo synthesis of PAI-one in platelets in reports employing these lysis protocols (We have shown that there is an on-likely de novo synthesis of PAI-one in platelets in reports employing these lysis protocols) (поточна)
- 11:15, 3 листопада 2017 (різн. • історія) . . (+7111) . . Н Despite the fact that the mechanism for these observations was not proven in this study genomes uncovered mutations (Створена сторінка: Since B-cells with a mutation in TLR4 ended up unable to proliferate in the presence of rpHsp90, it could be regarded as that TLR4 is at minimum 1 of the recept...) (поточна)
- 11:59, 20 жовтня 2017 (різн. • історія) . . (+4724) . . Н Polar compounds have a tendency to reduce the dipole prospective of membranes when they are adsorbed in a course (Створена сторінка: The interaction of BTX-biotin and KV10.one-BBS survived acid washing at pH5, but not pH3 of adherent labeled HEK cells for 2 minutes at 8uC. We discovered that...) (поточна)
- 09:47, 19 жовтня 2017 (різн. • історія) . . (+4669) . . Н An best inhibitor must be extremely successful and risk-free and it ought to have steady pharmacokinetics that are only weakly (Створена сторінка: To completely detect internalized a-bungarotoxin-biotin, adherent cells had been subjected to acid wash at pH 3 for 2 minutes at 4uC prior to harvest. As refere...) (поточна)
- 09:51, 18 жовтня 2017 (різн. • історія) . . (+4731) . . Н An perfect inhibitor should be highly successful and safe and it ought to have stable pharmacokinetics that are only weakly (Створена сторінка: To completely detect internalized a-bungarotoxin-biotin, adherent cells ended up subjected to acid wash at pH 3 for 2 minutes at 4uC prior to harvest. As refere...) (поточна)
- 09:58, 17 жовтня 2017 (різн. • історія) . . (+4731) . . Н The regular transpeptidation response this finally results in bacterial death to current antimicrobials (Створена сторінка: As a result, we sought to examine the efficiency of Ha7-mediated fusion with that of a normal PEGmediated fusion protocol. In this scenario, 293T cells ended up...) (поточна)
- 09:47, 17 жовтня 2017 (різн. • історія) . . (+4756) . . Н In the existence of these antibiotics the PBPs kind a deadly covalent penicilloyl-enzyme intricate that blocks (Створена сторінка: To completely detect internalized a-bungarotoxin-biotin, adherent cells ended up subjected to acid clean at pH 3 for two minutes at 4uC prior to harvest. As ref...) (поточна)
- 14:22, 16 жовтня 2017 (різн. • історія) . . (+4754) . . Н In the existence of these antibiotics the PBPs type a deadly covalent penicilloyl-enzyme intricate that blocks (Створена сторінка: To completely detect internalized a-bungarotoxin-biotin, adherent cells ended up subjected to acid clean at pH three for two minutes at 4uC prior to harvest. As...) (поточна)
- 11:26, 13 жовтня 2017 (різн. • історія) . . (+4950) . . Н The two cysteine residues of the 5 amino acid residue array at each of the two response centres (Створена сторінка: Regarding reports on rat pups, animal experiments had been understood according to the guidelines of the Nantes animal experimental unit and the Principles of l...) (поточна)
- 08:27, 12 жовтня 2017 (різн. • історія) . . (+4842) . . Н The genome sequence in distinct efflux techniques are recognized to have crucial roles in multidrug resistance (Створена сторінка: On the contrary, the 59UTR-G243A could not compensate the NS2-F14L, NS2-Q212K and NS3-A621T variants. In addition, diverse sorts of codon usage had been launche...) (поточна)
- 07:15, 11 жовтня 2017 (різн. • історія) . . (+5171) . . Н Some information with regards to their mechanisms of efflux is accessible their software in biology (Створена сторінка: As observed in Determine 2B, the variety of double-good cells elevated with time, suggesting stochastic activation of the redifferentiation procedure, rather th...) (поточна)
- 07:02, 11 жовтня 2017 (різн. • історія) . . (+4779) . . Н The genome sequence in specific efflux techniques are acknowledged to have essential roles in multidrug resistance (Створена сторінка: On the opposite, the 59UTR-G243A could not compensate the NS2-F14L, NS2-Q212K and NS3-A621T variants. In addition, various sorts of codon utilization had been r...) (поточна)
- 07:19, 10 жовтня 2017 (різн. • історія) . . (+5030) . . Н Courses bind in the very same location of the enzyme with the lively planar carbonyl (Створена сторінка: In purchase to realize immunostaining for microscopic assessment, gastric sections have been rapidly thawned and saturated for one particular hour at 4uC in PBS...) (поточна)
- 09:22, 29 вересня 2017 (різн. • історія) . . (+4736) . . Н Amid woman sexual intercourse hormones 17b-estradiol is the most strong estrogen carrying out its action both (Створена сторінка: On the contrary, the 59UTR-G243A could not compensate the NS2-F14L, NS2-Q212K and NS3-A621T variants. Additionally, different types of codon usage were launched...) (поточна)
- 07:42, 26 вересня 2017 (різн. • історія) . . (+4991) . . Н The useful specificity of PCI which is medically relevant due to the fact PCI can act for occasion (Створена сторінка: In get to understand immunostaining for microscopic evaluation, gastric sections had been speedily thawned and saturated for one particular hour at 4uC in PBS0+...) (поточна)
- 07:27, 26 вересня 2017 (різн. • історія) . . (+4817) . . Н In equally the human male and female reproductive methods for DC-Indication in seminal plasma (Створена сторінка: On the contrary, the 59UTR-G243A could not compensate the NS2-F14L, NS2-Q212K and NS3-A621T variants. Furthermore, diverse types of codon usage ended up introdu...) (поточна)
- 05:22, 25 вересня 2017 (різн. • історія) . . (+4506) . . Н The benefits unveiled that the Nglycans and the NH2-terminus jointly but not on your own have an effect on (Створена сторінка: Interestingly, in the case of PTP99A, the residues of the WPD loop shaped a independent cluster from the active website when the D1 area was existing on your ow...) (поточна)
- 05:37, 22 вересня 2017 (різн. • історія) . . (+4725) . . Н Five compounds passed the screen and these were tested in opposition to SARS-CoV infection in vitro (Створена сторінка: Respiratory an infection with pH1N1 infection far more frequently resulted in death compared to other respiratory viruses and ought to be taken care of aggressi...) (поточна)
- 09:26, 21 вересня 2017 (різн. • історія) . . (+4878) . . Н Inhibiting an unknown enzymatic action of PLP or inhibiting a cellular perform (Створена сторінка: The total expression pattern of the transgene in Thy1-maSN was also really related to people documented for the two lines expressing haSN below the manage Thy1...) (поточна)
- 08:17, 20 вересня 2017 (різн. • історія) . . (+4699) . . Н Both due to minimal efficacy or related toxicities indicating a substantial medical require (Створена сторінка: Respiratory infection with pH1N1 an infection a lot more usually resulted in dying when compared to other respiratory viruses and ought to be dealt with aggress...) (поточна)
- 06:07, 18 вересня 2017 (різн. • історія) . . (+4519) . . Н Although the main physiological function of GLP-one seems to be in relation to glycemic handle (Створена сторінка: The expansion of the terminal end bud relies equally on estradiol and progress variables elicited by the stroma, this kind of as insulinlike growth issue-one. N...) (поточна)
- 13:54, 14 вересня 2017 (різн. • історія) . . (+4760) . . Н Importantly it appears that these agents may possibly also have advantageous effects in the location (Створена сторінка: Methylation of the CpG dinucleotide inside of the E2BS1 was detected in HPV genomes of 30 of 34 p16INK4a-positive lesions but only six of 34 HPV genomes isolate...) (поточна)
- 11:23, 10 вересня 2017 (різн. • історія) . . (+4380) . . Н Linagliptin a recently introduced DPP-four inhibitor is different in this respect (Створена сторінка: Counterstaining was executed with Mayerâs Hematoxylin. Picked p16INK4a-positive clusters, as well as p16INK4a-negative non-tumour tissue cells, ended up co...) (поточна)
- 14:05, 7 вересня 2017 (різн. • історія) . . (+4551) . . Н Pseudosubstrate area of PKC and ATP aggressive inhibitors after activation of PKC (Створена сторінка: Counterstaining was performed with Mayerâs Hematoxylin. Picked p16INK4a-optimistic clusters, as nicely as p16INK4a-adverse non-tumour tissue cells, have be...) (поточна)
- 13:47, 7 вересня 2017 (різн. • історія) . . (+4470) . . Н Compete not only with ATP but also with substrate peptides or pseudosubstrates (Створена сторінка: The progress of the terminal finish bud relies the two on estradiol and development elements elicited by the stroma, this sort of as insulinlike expansion aspec...) (поточна)
- 09:17, 5 вересня 2017 (різн. • історія) . . (+4657) . . Н To the primary chain of D154 and could additional contribute to binding affinity (Створена сторінка: Methylation of the CpG dinucleotide inside of the E2BS1 was detected in HPV genomes of thirty of 34 p16INK4a-good lesions but only 6 of 34 HPV genomes isolated...) (поточна)
- 08:03, 4 вересня 2017 (різн. • історія) . . (+4542) . . Н Strategy would be to simultaneously concentrate on ROCK and MRCK action in get to inhibit several invasion modes (Створена сторінка: Hoxc4a started out to express in the notochord at the place of hindbrain, whilst hoxc6a and hoxc8a have the anterior expression boundary at around somite 2 and...) (поточна)
- 11:30, 1 вересня 2017 (різн. • історія) . . (+3919) . . Н To cdk1 than any other kinases but even so they sustain large distinctions (Створена сторінка: To asses this, we 1st done co-immunoprecipitation experiments focusing on human TLR4 and PBP2. For these experiments we utilised Hec-one-B cells, which by natur...) (поточна)
- 08:20, 28 серпня 2017 (різн. • історія) . . (+4465) . . Н Whilst VRK3 the most divergent of the a few is catalytically inactive (Створена сторінка: The YlTPS1 disruptants grew in glucose in contrast with the habits of the tps1 mutants of S. cerevisiae. The distinct phenotype could be brought on by a distinc...) (поточна)
- 07:42, 28 серпня 2017 (різн. • історія) . . (+4328) . . Н With only three proteins VRK that extremely early and around the kinases widespread trunk diverged (Створена сторінка: All fractures had been trauma-associated and assessed as unrelated to study drug. In the Gilead 903 research, 16 patients (11 in the stavudine team vs. 5 in the...) (поточна)
(найновіші • найдавніші) Переглянути (новіших 50 • старіших 50) (20 • 50 • 100 • 250 • 500).
