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- All experiments had been conducted in accordance with Animal Care Committee of Nanjing Health-related University
- All experiments had been executed in accordance with the Nationwide Institutes of Health Guidebook for the Treatment and Use of Laboratory Animals
- All experiments have been performed in triplicates plus the standard deviation was calculated
- All experiments were performed with approval of the ethical committee of the Katholieke Universiteit Leuven
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- All immunostained slides were reviewed by an skilled immunopathologist (AN) to render an evaluation of VEGFR2 expression in tumor vasculature and cells
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- All rats were maintained in a room equipped with an air-filtering system, and the cages and water were sterilized
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- All steps of animal welfare, maintenance, and medical care were also performed by University of Ottawa ACVS
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