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  1. The ECD of LRP1b is cleaved by several metalloproteinases, including ADAM17 and other members of the ADAM family, in the initial step of receptor processing and leads to shedding into the extracellular space where its function has not Figure 3
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  8. The E protein is a major target in the immune response to DENV, and structural analysis demonstrated that some E epitopes are preferentially exposed in immature virions
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