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Finally, a cell suspension containing 104?Hep2 cells/0.1?mL was added. Cell and virus controls were included in each batch. The plates were examined daily (3�C5?days) for the development of cytopathic effect. When the virus controls showed complete cytopathic effect, the final results were recorded 24?h later. The highest dilution of serum pool that protected the cultures was recorded. Results were expressed as log10 reciprocal titres (log10 titre 1?:?10?=?1). Student��s t-test (paired samples test) was used to compare the mean NT titres of four age groups (1�C10, 11�C20, 21�C30 and 31�C40?years) Enzalutamide cost against each Sabin vaccine strain (Sabin1, Sabin2, or Sabin3) with those against same serotype OPV derivatives. A one-way ANOVA test (Duncan��s multiple range test) was used Venetoclax solubility dmso to compare the mean NT titres against the Sabin vaccine strain and OPV derivatives of the same serotype between the 1�C10-year, 11�C20-year, 21�C30-year and 31�C40-year age groups. Table?1 shows the serotype and the recombination site of each of the 19 OPV derivatives identified in previous studies [12�C17]. The serotype of OPV derivatives was identified as P1 for five, as P2 for six, and as P3 for eight. The majority of OPV derivatives were characterized as OPV-related polioviruses displaying Histone demethylase 1.87% divergence from the VP1 region of reference strain Sabin1 and a recombination event between the Sabin1 vaccine strain and a member of enterovirus group?C in the 2A genomic region. Table?2 shows the statistical analysis of the log10 reciprocal NT titres against Sabin vaccine strains and OPV derivatives. The population of the 1�C40-year age group shows significantly lower NT titres against two Sabin1 derivatives (742 and 522) in comparison with the Sabin1 vaccine strain. No significant differences in NT titres were observed for Sabin2 and Sabin3 derivatives in comparison with the Sabin2 and Sabin3 vaccine strains, respectively. A sequential decrease in NT titre was observed from the 1�C10-year age group to the 11�C20-year and 21�C30-year age groups in all three poliovirus types (P1, P2, and P3). Specifically, a significant decrease was observed from the 1�C10-year to the 11�C20-year age group for poliovirus type?1 and from the 1�C10-year age group to the 11�C20-year and 21�C30-year age groups for poliovirus types?2 and 3. An increase in NT titre was observed from the 21�C30-year to the 31�C40-year age group for poliovirus types?1 and 3, but not for poliovirus type?2. However, this increase was significant only for poliovirus type?3.