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Tumor recurrence was suspected when there was a progressive elevation of serum AFP and/or ultrasonographic evidence of a new hepatic lesion that was confirmed by dynamic CT scan, MRI or position emission tomography (PET). HCC recurrence was defined as re-hospitalization with a primary diagnosis of HCC after the index CX 5461 admission date and a treatment modality for HCC recurrence, such as surgery, transarterial chemoembolization, percutaneous ethanol injection, radiofrequency ablation, or liver transplantation, during the study period. Disease-free survival was measured from the date of surgery to the date of recurrence. Follow-up of patients was continued until HCC recurrence, death, or August 5, 2013. Causes of death were also investigated. Statistical methods Descriptive analyses of the variables were conducted using SPSS 16.0 (SPSS Inc., Chicago, IL, USA). Univariate analyses were performed using the Chi-squared test for categorical Dipivefrine variables and the independent-samples t-test for discrete variables. Cumulative incidences were calculated using the Kaplan-Meier method. Clinicopathological prognostic factors were evaluated using the univariate Kaplan�CMeier method and compared with the log-rank test to identify the prognostic predictors for recurrence. Multivariate regression analysis was performed using Cox proportional hazards models to identify the independent prognostic factors for recurrence. Variables to be entered into the multivariate analysis were selected based on the results of the univariate analyses (p this website (ROC) curve analysis was used to compute the area under the ROC curves for different factors. The performances of the factors in predicting HCC recurrence were compared using the Chi-squared test for categorical variables and the t-test for discrete variables. A value of p 41 U/L. Serum HBsAg levels in most patients (72.4%) were �� 4000 S/CO. HBV DNA levels in nearly half of the patients (44.6%) were