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The burden of endotoxins, inflammatory cytokines, and oxidative stressors at the level of maternal�Cfetal unit can also be increased by periodontitis.[7] Potent vascular stressors like soluble intercellular adhesion molecules (sICAMs) are found to be increased in periodontitis,[13] thus compounding preeclampsia. So, any maternal infection or inflammatory disease like periodontitis and atheroma formation can initiate and propagate acute uteroplacental atherosis and preeclampsia.[14] Oral cavity and systemic diseases form a two-way street, i.e. both entities can affect each other. Golub et al.[15] proposed a ��two-hit�� model for chronic periodontitis and systemic diseases like arthritis and osteoporosis. They concluded that the periodontopathic bacteria provided one ��hit,�� whereas systemic inflammations elevating the Selleckchem Pexidartinib levels of pro-inflammatory biomarkers like C-reactive protein (CRP), IL-6, and matrix metallopeptidase-9 (MMP-9) in serum or plasma act as a second ��hit.�� It is possible that preeclampsia could also lead to an aggravation of pre-existing periodontal problems or even co-induce periodontal destruction, but further studies regarding this co-relation have to be carried out. The aim of the present study was to assess the risk association between maternal periodontitis and preeclampsia. The present study was conducted on 1240 patients who were selected based upon their demographic, obstetric, and medical history from the medical records under a standardized GUCY1B3 protocol to eliminate any possibility of a bias. Clinical signs of inflammation and periodontal tissue destruction were assessed using BOP, PPD, and CAL based upon the criteria proposed by Lopez et al.[16] The statistical analysis showed that the percentage of sites with BOP, PPD, and CAL was more in group A as compared to group B [Table 1]. On investigating BOP, PPD, and CAL in both the groups, there were statistically significant difference (P preeclamptic group and the normotensive group as shown in Table 2. Findings from the present study showed BKM120 in vivo a significant risk association between maternal periodontitis and preeclampsia after analysing other variables like maternal age, chronic hypertension, previous preterm birth and number of prenatal visits. The adjusted OR for preeclampsia was 19.8 (95% CI 7.80�C48.94; P