Twelve MK-2206 Discussion Suggestions

?nosocomialis, respectively. We excluded 129 patients with polymicrobial bacteraemia and 288 patients with a positive blood culture attributable to another source of infection. Eight patients with community-acquired A.?baumannii pneumonia, which is a distinct clinical entity, were excluded [23,25]. We also excluded nine patients with HCAP (seven caused by A.?baumannii and two by A.?nosocomialis). The final population that met the criteria for entry into the study this website consisted of 121 patients with A.?baumannii and 131 patients with A.?nosocomialis nosocomial pneumonia. The demographic and clinical characteristics of the study patients are summarized in Table?1. Patients with A.?baumannii had more collagen vascular diseases, and more frequently received corticosteroids and had nasogastric tubes than those with A.?nosocomialis. The Charlson co-morbidity scores on admission were similar for the two Acinetobacter species. However, patients with A.?baumannii had significantly higher APACHE II scores (p 0.003) and more frequently presented with shock at the time TRIB1 positive blood cultures were obtained. Patients with A.?baumannii had lower haemoglobin levels and platelet counts, and more frequently presented with leukocytosis or leucopenia, but they did not have more haematological malignancy (data not shown). Pulmonary lobar consolidation was significantly more frequent in patients with A.?baumannii pneumonia (p 0.03), while pleural effusion and bilateral lung involvement were about the same with both Acinetobacter species. The antimicrobial susceptibility profiles of the clinical isolates of A.?baumannii and A.?nosocomialis are shown in Table?2. A.?baumannii exhibited significantly higher rates of resistance to all antimicrobials tested, with the exception of colistin. None of the A.?baumannii isolates were resistant to colistin. In contrast, 26.7% of the A.?nosocomialis isolates were resistant to colistin (p?Ibrutinib solubility dmso (9?days; interquartile range, 1�C32?days) than A.?nosocomialis pneumonia (27?days; interquartile range, 8.5�C60.5?days) (p 0.003). Kaplan�CMeier survival curves reflected the early occurrence of death within a few days following pneumonia for patients with A.?baumannii. This was followed by slightly higher rates of death for A.?baumannii than A.?nosocomialis species thereafter (p?