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In the present study, we investigated the knowledge of the harmful health hazards of smoking on chest physicians' practices in helping tobacco control. In this cross-sectional study, more than 60% of the chest physicians surveyed were aware of the harmful effects of smoking and provided smoking cessation advice for their patients. We found that physicians who were more aware of the health hazards of smoking were more likely to actively provide smoking Vandetanib molecular weight cessation advice in the clinic (P? by 36%, underlining a dire need for updates in current knowledge of smoking-related diseases among Chinese physicians, especially those working at primary hospitals. It is expected that greater awareness of smoking-related conditions would encourage physicians to advice patients to stop smoking. It makes sense that chest physicians may be more likely to successfully persuade their patients to quit smoking because their advice is from a professional perspective based on specialized knowledge. Yes n ( % ) No n ( % ) Physicians' Oxalosuccinic acid awareness rate of the hazards of smoking, based on multifactorial analysis, was correlated with the level of hospitals and smoking status. Chest physicians at tertiary hospitals showed significantly higher awareness scores and the practice to offer smoking cessation advice than those at primary or secondary hospitals (P?Bosutinib levels of hospital. The education programmes sponsored by pharmaceutical companies were mostly offered to physicians in tertiary hospitals, and more smoking cessation education targeting at physicians in primary and secondary hospitals may be needed. Smoking cessation advice practice was correlated with physicians' smoking status and educational background, but not with the levels of hospital, position or department affiliation (respiratory medicine or internal medicine). This finding was consistent with previous studies showing that advice enthusiasm in physicians was negatively correlated with their smoking status.