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The Kaplan-Meier product-limit method with log-rank comparisons was used to estimate survival distribution. The Cox's proportional hazards model was used to assess the prognostic significance of factors in the univariate and multivariate analyses. P-values of in our hospital. All the patients had developed antiandrogen syndrome and received alternative antiandrogen therapy, and 29 patients (74%) received ethinylestradiol. The patient characteristics are summarized in Table I. The median age at initiation of DOC was 71 years (range, 55�C83 years) and the median serum PSA level at initial diagnosis was CX-5461 research buy 187 ng/ml (range, 2.0�C1,711 ng/ml). The median Dipivefrine number of DOC cycles was 7 (range, 1�C45 cycles). The median Gleason score was unknown (n=4), 3+3 (n=3), 3+4 (n=6), 4+3 (n=4), 4+4 (n=5), 4+5 (n=9), 5+4 (n=5) or 5+5 (n=3). The median PSA level at the initiation of DOC treatment was 50.1 ng/ml (range, 0.01�C1,710 ng/ml). There was no association between the PSA levels at initiation of DOC treatment and PSA response. Table I. Patient characteristics (n=39). Of the 39 patients, 13 (33%) responded to treatment with a decrease to Forskolin manufacturer 2 (5%) and 2 (5%) patients, respectively. One patient succumbed to interstitial pneumonia. Table II. Adverse events of grade ��3 in the 39 CRPC patients treated with weekly low-dose docetaxel chemotherapy. Survival analysis The OS after treatment ranged from 2 to 54 months (median, 16.7 months) (Fig. 1). The results of the uni- and multivariate analysis of predictors of OS in the patient cohort are presented in Table III. In the univariate (P=0.019) as well as the multivariate analysis (hazard ratio = 6.913; 95% confidence interval: 1.147�C41.669; P=0.035), the decrease of the PSA level to