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The number of paediatric cases among the estimates was determined using data reporting 36.4% [20] and 10.1% [21] of CA-MRSA cases as selleck compound a range of costs. Study 1 represents the lower estimate, as they used the CDC definition, and Study 3 represents the upper estimate, as they used a 48-h criterion to define CA-MRSA cases. As SSTIs represent ?75% [22] of infections, we determined their burden separately using estimates from Study 3 and Study 4, which reported 164.2 per 100?000 CA-MRSA SSTIs [10]. A similar approach estimated the annual burden for two particularly high-risk sub-populations: jail (prevalence, 4.5�C79.7% [23]) and military populations (prevalence, ��5% [24]). David et?al. [25] evaluated SSTI incidence and aetiology among detainees at Cook County Jail, reporting 15.84 MRSA SSTIs per 1000 detainee-years (mean age, 33?years) with a census of 10?000 detainees at a given time. An army installation study estimated 35 CA-MRSA SSTI cases per 1000 soldiers (mean age, 22?years) [24]. These incidence estimates multiplied by cost-per-SSTI-case determined the annual economic burden in these sub-populations. One-way sensitivity analyses systematically varied key parameters one at a time throughout their ranges (Table?1). Monte Carlo probabilistic sensitivity analysis simultaneously varied all FMO5 parameters throughout their ranges. Table?2 shows the median and 95% range of the total direct medical costs of a CA-MRSA case from our simulations. Varying the SSTI care-seeking probability (10�C40%) altered this cost in most cases by this website impact (increasing by ��$500). A child not surviving has higher productivity losses than an adult; however, we observe greater productivity losses for adults due to higher mortality rates. At baseline hospitalization values (5.7% for ��18?years, 25% for