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Arterial tonometry Arterial tonometry was performed transcutaneously over the right radial artery. Recorded radial artery waveforms were calibrated VX-770 chemical structure by synthesizing a central (aortic) pressure waveform using a generalized transfer function (Sphygmocor, AtCor Medical) (Gallagher et?al. 2004). Both systolic and diastolic aortic BP was derived using this technique. The synthesized central aortic waveform was used to quantify central augmentation index as the percent increase in the peak systolic waveform from the systolic shoulder. Central augmentation index was also calculated at a standardized heart rate of 75 beats/min. Blood biochemistry Eicosapentaenoic acid and docosahexanoic acid content of erythrocytes were determined in a subgroup of young (n?=?8) and older subjects (n?=?8), using established laboratory methodologies (Harris et?al. 2012). Other biochemical parameters were obtained using standard laboratory methods by our hospital's clinical laboratory. Statistical analysis Differences in baseline subject characteristics were determined by t-test and repeated measures ANOVA was used to determine effects of the intervention. Specific contrasts were made using Newman�CKeuls post hoc tests. Statistical significance was established at P? Subject characteristics before (Pre) and after (Post) n-3 supplementation are presented in Table?Table1.1. Older subjects were of shorter stature Ribonucleotide reductase and lower body mass than the young, although body mass index was similar in the two groups. Blood lipids including CH5424802 clinical trial total, LDL, and HDL cholesterol, as well as triglycerides were greater (P? in young and older adults (Pre) and decreased significantly with n-3 supplementation in the subject population as a whole (i.e., in young and older subjects combined), but not in the individual groups (i.e., not in the young or older groups individually). Eicosapentaenoic acid and docosahexanoic acid content of erythrocytes was similar in young and older subjects before supplementation (Pre) and increased with supplementation (Post; P?