Couple Of Clear Info Regarding MK-2206 Outlined

?1). Specifically, there were 12 (14%) deaths in the underweight, 36 (10%) in the normal weight, 21 (9%) in the overweight and 10 (4%) in the obese category. Table?2 displays those variables significantly associated with in-hospital mortality in univariable analyses. In unadjusted analysis, obesity BTK inhibitor was associated with a significantly lower risk of mortality compared with the normal weight category (4% vs. 10% mortality for normal weight; unadjusted OR, 0.39; 95% CI, 0.19�C0.81; p?0.01; Table?3). In fully adjusted models, obesity was still independently associated with a significantly lower rate of in-hospital mortality compared with normal weight (adjusted OR, 0.46; 95% CI, 0.22�C0.97; p?0.04). However, mortality rates in the underweight (adjusted OR, 1.13; 95% CI, 0.54�C2.4; p?0.7) and overweight groups (adjusted OR, 0.94; 95% CI, 0.52�C1.69; p?0.8) were not significantly different compared with normal BMI (Table?3). The adjusted model for in-hospital mortality performed well according to the c-statistic (0.78, p?TRIB1 restricted to the 680 patients with chest-radiograph confirmed pneumonia, the findings were even more striking: there were 12 (17%) in-hospital deaths in the underweight, 30 (11%) in the normal weight, 19 (11%) in the overweight and 6 (4%) in the obese category. Even though the sample size was reduced by 227 patients, the independent association between obesity and in-hospital mortality became larger and more significant: adjusted OR, 0.31; 95% CI, 0.12�C0.78; p?0.01 ( Table?4). The adjusted model for in-hospital mortality in this subgroup analysis performed well according to the c-statistic (0.79, p?MK 2206 significant (adjusted OR, 0.25; 95% CI, 0.10�C0.63; p?0.004). Third, there were 179 (20%) ICU transfers and 65 (7%) re-hospitalizations within 30 days. Compared with normal weight, there was no independent association between obesity and ICU transfer (adjusted OR, 0.78; 95% CI, 0.50�C1.21; p?0.3) or 30-day readmission rates (adjusted OR, 0.81; 95% CI, 0.41�C1.61; p?0.6 and Table?4). The same pattern held true when non-fatal endpoints were examined in analyses restricted to patients with abnormal chest radiographs (Table?5).