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See Figure 2(A) (lower-left graph) for a clear example. The Suga�CSagawa relation together with the Senzaki-elastance allow the calculation of the pressures. To be specific: for a given moment, first, the elastance is calculated using the Senzaki et al��s elastance function and, then, the pressure is calculated from the elastance and the volume using Suga�CSagawa��s relation. The calculation of the volume is discussed below. In the ventricular iso-volumetric phase, both valves are closed with the conditions PAT(t) BMS-754807 clinical trial for ventricular volume VLV(t). That is: FVL(t)=FAT2VL(t)?FAR(t),withFAT2VL(t)=FAR(t)=0?FVL(t)dVVL(t)dt=0dVVL(t)dt=0 (11) Note that, dVLV(t)/dt = 0, implies that VLV(t) is constant as expected in the iso-volumetric phase. Likewise, the state equation for the Windkessel pressure PW(t) is found: FCAR(t)=FAR(t)?FC(t),withFAR(t)=0?CAR(t)dPW(t)dt=?PW(t)?PVS(t)RC?CAR(t)dPW(t)dt+1RCPW(t)=1RCPVS(t) (12) Finally, the state equation for the venous pressure PVS(t) is found: FCVS(t)=FC(t)?FVS(t)?CVS(t)dPVS(t)dt=PW(t)?PVS(t)RC?PVS(t)?PVS0(t)RVS?CVS(t)dPVS(t)dt+(1RC+1RVS)PVS(t)=1RCPW(t)+1RVSPVS0(t) Protein Tyrosine Kinase inhibitor (13) In the ventricular ejection phase the atrial�Cventricular valve is closed with condition PFKM PAT(t) The state equation for the atrial volume VAT(t) equals the state equation in the iso-volumetric phase, ie, Eq. (10). The state equation for the ventricular volume VLV(t) is: FVL(t)=FAT2VL(t)?FAR(t),withFAT2VL(t)=0?dVVL(t)dt=PVL(t)?PW(t)RVL2AR+ZAR0?dVVL(t)dt+1RVL2AR+ZAR0PVL(t)=1RVL2AR+ZAR0PW(t) (14) The state equation for the Windkessel pressure PW(t) is: FCAR(t)=FAR(t)?FC(t)?CARdPW(t)dt=PVL(t)?PW(t)RVL2AR+ZAR0?PW(t)?PVS(t)RC?CAR(t)dPW(t)dt+(1RVL2AR+ZAR0+1RC)PW(t)=1RVL2AR+ZAR0PVL(t)+1RCPVS(t) (15) The state equation for the venous pressure PVS(t) takes the same form as the state equations for the iso-volumetric phase, ie, Eq. (13). In the ventricular filling phase, the atrial�Cventricular valve is open with condition PAT(t) �� PVL(t) and the ventricular�Carterial valve is closed PVL(t)