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2). Annular fissure toward the anterior of disc was not considered during rating of annular disruption. Fig. 1 General degeneration of Dallas discogram description. (A) Grade 0, no change. (B) selleckchem Grade 1, local (50%). Fig. 2 Annular disruption of Dallas discogram description. (A) Grade 0, none. (B) Grade 1, into inner annulus. (C) Grade 2, into outer annulus. (D) Grade 3, beyond outer annulus. Two independent observers who were blinded to the clinical and discographic findings of patients performed all measurements. Treatment and outcome measure Patients with positive discography were recommended for treatment with intradiscal steroid injection. For the patients who received intradiscal steroid injection, 20 mg of triamcinolone acetonide (total 0.5 mL) was injected slowly and gently into the center of the nucleus pulposus of the target intervertebral disc under fluoroscopic guidance. Baseline data was obtained before the procedure, and clinical outcome was determined by numerical rating scale (NRS) assessed at 3 months after the procedure. Statistical analysis Categorical data were compared by the chi-square test and linear by linear association. The spearman correlation and binary logistic regression analysis was used to examine the correlation among age, grade of general degeneration, grade of annular disruption AZ191 and positive discography. Multivariate linear regression analysis was performed to identify association among age, grade of general degeneration and prognosis. Statistical analyses were performed using SPSS Statistics ver. 20 software (IBM, Armonk, NY, USA). Significance was determined when the p-value was selleck 3 Distribution of age, examined level and positive discography. Correlation between morphology of disc and positive discography In the case of general degeneration, the positive rates of grade 0, 1, 2, and 3 accounted for 0%, 34.3%, 57.9%, and 56.7%, respectively (p-value for linear by linear association