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Injection diclofenac 1.5 mg/kg was given intramuscularly as rescue analgesic. Time for first rescue analgesic and total number of analgesic doses used were noted. Nausea/vomiting was treated with injection ondansetron 4 mg IV. Pruritus was treated with injection promethazine 25 mg IM which was repeated after 1 h if needed. Oxygen by Hudson mask was provided if SpO2 decreased to Megestrol Acetate of Gemcitabine molecular weight (difference of 155 min and standard deviation [SD] 153 min) according to time for first analgesic demand.[10,11] A sample size of 21 patients in each group were needed for 90% power of study with 5% significance level. Twenty five patients were included in each group to allow possible drop outs. Data are expressed as either Mean �� SD or numbers and percentages. Demographic data, type and duration of surgery, characteristics of spinal block were analysed using independent two sample t-test. The time for first analgesic demand and total analgesic requirements, regression of sensory and motor blockade were compared using Mann�CWhitney U-test. Intraoperative bradycardia and hypotension were analysed as number of episodes and compared with independent t-test. Rest of the side effects were compared using Chi-square or Fisher's exact test, whichever was applicable. A Kaplan�CMeier survival curve was obtained for time for first analgesic demand (Figure 1). P Birinapant purchase significance (P = 0.056) considering 95% of confidence interval (0.000�C0.058). (Figure 1) Total number and amount of analgesics needed in 24 h was also same in both groups [Table 2]. Two patients in group D and three patients in Group M did not require any analgesic in 24 h. There was no significant difference between the onset of sensory and motor block in both groups [Table 3]. Time taken to reach T10 was significantly less in Group D (P = 0.004). Thirty-six per cent of patients in Group D achieved T2 level, whereas in Group M 44% of patients reached T4 level and none to T1, though the difference was not statistically significant.