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There were no significant differences between the groups for the following CDK inhibitor parameters: end-diastolic volume, ejection fraction (EF), cardiac output, and stroke work. The L/M was improved by both PK10453 and imatinib, compared to vehicle, in the MCT model (V [n = 4]: 0.55 �� 0.1; D8 [n = 12]: 0.94 �� 0.08; I8 [n = 5]: 0.99 �� 0.07; P pressure in the vehicle group was 51.4 �� 8.9 mmHg, and that in the imatinib group was 41.5 �� 3.5 mmHg. At treatment day 9, the PA systolic pressure in the vehicle group was 80.4 ��14.2 mmHg, and that in the imatinib group was 75.1 �� 7 mmHg (P not BGB324 significant). Figure 6 Telemetry study in the rat monocrotaline plus pneumonectomy (MCT+PN) model. Pulmonary artery (PA) systolic pressure was measured over time in ambulatory rats. Top, PK10453; V: vehicle (n = 5); D: 4-minute exposure to PK10453 3 times/day (n = 6). Pound ... Efficacy study 5: measurement of RV pressure and PV loops in the MCT+PN model; PK10453 dose-response study In a separate cohort of animals, the MCT+PN model was developed as described above. RV pressure was obtained after 14 days of vehicle exposure, and PK10453 treatment was carried out with 4-minute (D4) and 8-minute exposures Ramoplanin (D8) 3 times a day. In the vehicle group (V; n = 9), RVSP was 75.7 �� 7.1 mmHg, that in the D4 group (n = 10) was 40.4 �� 2.7 mmHg, and that in the D8 MCT+PN group was 43 �� 3.0 mmHg (P