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The features leading Alectinib to these two intensity extrema must be adjacent in order for this relationship to be valid. For our study, Imax and Imin were determined based on the average intensity profile across each ROI as described previously. Ex vivo porcine abdominal skin was obtained and prepared as described previously for imaging experiments. The resulting specimens (N?=?10) were 1.44?��?0.34?mm thick, with a thickness range between 0.85?mm and 2.00?mm. Handling, storage, and usage followed the same process detailed previously. Porcine skin specimen thickness was calculated dynamically during mechanical compression. Using a BOSE? ElectroForce? 3100 mechanical testing instrument, tissue displacement, load, and light transmission were measured simultaneously. This instrument has a displacement resolution of 1.5??m and a loading resolution of 6?mN with a 22?N load cell, which provides satisfactory displacement and load resolution for this study. As shown in Figure 4, ex vivo porcine skin samples were locally indented by a hemispherically tipped transparent sapphire rod with a diameter of 3?mm. The rod was epoxy bonded to a polycarbonate housing fastened to the electromagnetic displacement cell of the ElectroForce PI3K inhibitor instrument. A 670?nm laser source and a collimator delivered light to the transparent rod and the underlying tissue. Tissue samples were placed beneath the rod on a glass sheet attached to a piece of aluminum square tubing. A 12.5?mm diameter hole in the tubing beneath the glass sheet allowed light to be transmitted through the tissue to a large-area photodetector (1?cm?��?1?cm), which generated an electrical signal proportional to the light transmitted through the sample (Newport detector #818 and optical power meter #1931-C). During compression, the instantaneous optical power transmitted through the sample was recorded, allowing simultaneous dynamic measurement of tissue thickness, load, and light transmission. Transient measurement of optical power transmission through tissue during localized compression provides insight into the correlation between the effects of load and tissue thickness change on light transmission. A compression protocol was developed Tryptophan synthase to evaluate light transmission during two separate compression stages: 1) displacement-controlled compression to a final tissue thickness of 0.5?mm at a displacement rate of 0.02?mm/second (strain rate of ?10?2?second?1) and 2) dwell at constant tissue thickness of 0.5?mm for 120?seconds. Displacement, load, and optical power transmission were recorded with the same software at a rate of 50?Hz. Both initial and dynamic tissue thickness were critical parameters in this mechanical compression experiment. The indenter was first brought into contact with the glass sheet and this position, xg, was recorded.