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Patients with Prader-Willi syndrome were not reported in this study. In all patients, the mean age at the start of HRT therapy was 15.7 yrs, mean height was 157.2 cm, mean age at adult height was 19.4 yrs, and mean adult height was 171.0 cm. There were no significant differences in age at the start of HRT and at adult height among the disease groups. There were significant differences in height at the start of HRT (p (Table 3). The mean height PFKM gain during puberty of all patients was 14.0 cm, and there were no significant differences in height gain during puberty among the disease groups BMS-754807 supplier (Table 3). Table 3 Clinical characteristics at start of HRT and at reaching adult height of the groups of children with MHH As an initial HRT, 30 patients received testosterone monotherapy, 12 patients received hCG monotherapy, and 13 patients received hCG-rFSH combination therapy (Table 4). There were significant differences in age at the start of HRT between patients who received testosterone monotherapy and patients who received hCG-rFSH combination therapy (p = 0.03). There were no significant differences in adult height among the initial HRT groups. Table 4 Initial HRT for MHH Fourteen patients with acquired MHH and 14 patients with idiopathic MHH had been receiving HRT with GH therapy. There were no significant differences in adult height between patients with and without GH treatment (Table 5). Table 5 Adult height of MHH patients with and without GH (2) Correlation between age and height at the start of HRT (Fig. 1) Fig. 1. Correlation between age and height at the start of HRT. Figure 1 shows the correlation between age and height at the start of HRT in MHH.?There was a significant positive correlation (r = 0.728, p BLZ945 solubility dmso at the start of HRT and adult height. As shown in Fig. 2, no correlation was observed between age at the start of HRT and adult height.?The mean adult height of 13 patients who started HRT at younger than 14 yrs old was not significantly different from that of 42 patients who started at 14 yrs old or older (171.6 cm vs. 171.0 cm). Comparing of Fig. 1 with Fig. 3, the mean increase in height before pubertal induction with HRT [1.8 cm/yr (Fig. 1)] is not greater than the mean decrease in pubertal height gain [2.1 cm/yr (Fig. 3)] anymore. Therefore, regardless of the age at the start of HRT, no significant differences were observed for adult height. Fig. 3. Correlation between age at the start of initial HRT and height gain during puberty.