Impartial Insider Report Reveals An Unanswered Questions On PTEN

97, df = 6, p = 0.006, McFadden pseudo-R2= 0.212). Table ?Table33 lists odds ratios, z-statistics, and the associated p-value for each predictor. As can be seen from Table ?Table33, we detected a marginal between-group age difference. On average, HR infants were slightly older than LR infants at the time of the targeted age 6-month examination, and a 1-month increase in age at the time of examination was associated with decreased odds of belonging to the LR group by a factor of 0.40 (p = 0.076). This age difference could have afforded the HR group a slight performance advantage. FIGURE 2 Spine plots of behavioral responses during the three phases of the ball-rolling task. The majority of children in HR and LR groups demonstrated context appropriate looking behavior TSA HDAC by (A) looking immediately at the ball and/or examiner during the Ready ... Table 3 Predictors of familial risk for ASD at PD0332991 clinical trial age 6 months. The logistic regression model revealed a significant effect of MSEL Fine Motor score on familial risk (HR vs. LR group). Analysis of MSEL motor scales revealed that, on average, HR infants displayed less mature fine motor skills; a one unit increase in MSEL Fine Motor score increased the odds of belonging to the LR group by a factor of 1.62 (p = 0.020). In contrast, 6-month-old MSEL Gross Motor scores were not predictive of familial risk (p = 0.407). After controlling for age and fine and gross motor skills (based on MSEL Fine and Gross Motor scores), a main effect of anticipation on familial risk group (X2 = 8.4, df = 3, p = 0.039) was identified during the ��Go�� phase of the task. Regardless of the maturity of the movement, moving a hand/arm in anticipation of the approaching ball (score of 1�C3; see Table ?Table22) was associated with decreased odds of belonging to the HR group. Displaying no movement PTEN in anticipation of catching the ball increased the odds of belonging to the HR group by a factor of 5.78 (p = 0.007) compared to displaying a delayed hand/arm movement (score of 1), by a factor of 3.32 compared to successfully anticipating the ball but having to readjust hand position after making initial contact (score of 2) (p = 0.053), and by a factor of 4.57 compared to successfully anticipating the ball with the proper hand orientation to grab the ball (score of 3) (p = 0.023). In other words, HR infants were less likely than LR infants to initiate action in anticipation of the approaching ball (Figure ?Figure2C2C). Association between Anticipation at Age 6 Months and Social and Sensorimotor Functioning at Age 14 Months A two-way ANOVA was conducted to examine relationships among familial risk for ASD (two levels), anticipation behavior at age 6 months (four levels) and total ADOS score at age 14 months. There was a statistically significant main effect of familial risk on total ADOS score [F(3,78) = 18.656, p