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These guidelines define the reference range and minimum significant changes (MSC) in TRACP-5b as 120�C420 mU/dL and 12.4%, respectively. Statistical analyses Baseline data are shown as means �� standard deviations (SD). The ratios (%) of differences from baseline were regarded as statistically significant when the 95% confidence interval (CI) did not include zero. Data were statistically analyzed using Student��s t-test, Fisher��s exact probability test, the chi-square test and ANOVA, and values were considered statistically significant at P check details were observed between groups in age or baseline TRACP-5b values. Figure 1 Per cent changes of TRACP-5b in treatment na?ve group. Figure 2 Per cent changes of TRACP-5b in VD-switch group. (1) Drug-na?ve group (Table 1, Figure 1) Mean and median per cent changes Enol of TRACP-5b in both the RLX+ELD and BP+ELD groups significantly decreased during the first 6 months by 34.8 and 54.1%, respectively, and 39.7% and 61.0% (p = 0.002), respectively, which is consistent with BP being a more potent antiresorptive drug than RLX. The rates of patients with TRACP-5b decreasing beyond MSC did not significantly differ between the RLX+ELD and BP+ELD groups (77.8% vs 94.2%, p = 0.067). Values of TRACP-5b decreased below the reference value ( 2, ?,33) Figure 3 Tertile changes in VD-switch group. Mean and median per cent changes of TRACP-5b in both treatment groups significantly decreased during the first 6 months. The mean and median per VTX 2337 cent changes in the RLX+ELD and BP+ELD were ?21.1 and ?13.0%, respectively, and ?24.5 and ?21.9%, respectively, with no significant differences (p = 0.532). The rates of patients with TRACP-5b values that decreased below the MSC in the RLX+ELD and BP+ELD groups were 70.5% vs 60.5% (p = 0.137). Five (3.6%) of 139 and three (3.9%) of 76 patients in the RLX+ELD and BP+ELD groups, respectively, had TRACP-5b values that decreased below the reference range (p = 0.897). Stratification of the baseline values significantly differed among the highest, middle, and lowest tertiles of patients in the RLX+ELD group (?30.3, ?21.1 and ?11.6%, respectively; p