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However, in our case report, we used oral cyclophosphamide in accordance with the current standard of care. The patient Bcr-Abl inhibitor reported here developed signs of glomerulonephritis UNC2881 patient, CF was diagnosed at the age of 2 years (genotype ��F 508/��F 508) with pulmonary symptoms and failure to thrive. She has a history of a chronically impaired digestion and of infections of the respiratory tract, infections treated with high-dose intravenous antibiotics. Diabetes mellitus (DM) was diagnosed at the age of 28 years. When she was 41 years old, she developed oedema and nephrotic syndrome. Laboratory data revealed proteinuria AP24534 chemical structure 8 g/day and glomerular filtration rate 74 mL/min. Kidney biopsy disclosed SAA amyloidosis. She was commenced on oral colchicine, 1 mg/day progressively increased to 2 mg/day. After 1 year of this treatment, proteinuria is 3 g/day and renal function is slightly improved, with a creatinine clearance of 83 mL/min. A moderate reduction in SAA protein concentration (from 325 to 229 mg/L) was observed. Case 2 In the second patient, CF was diagnosed at the age of 21 years (genotype ��F 508/N) owing to her family history. Pulmonary infections required intravenous antibiotics every 3 months. DM was diagnosed at the age of 38 years. At the age of 41 years, she developed proteinuria of 1.4 g/day with decreased renal function (glomerular filtration rate 50 mL/min). Light microscopy (Figure 1) and immunohistochemistry revealed renal amyloidosis of the SAA type.