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To test the activity of T cells, we cultured lymphocytes stimulated with Con A, and measured the content of cytokines in the medium. Th1 and Th2 cells are classified by the type of cytokines (17,18,19,20). It is well known that Th1 cells typically produce IL-2 and IFN-��, and Th2 cells produce IL-4, IL-5, and IL-13. IL-2 and IFN-�� are pro-inflammatory cytokines that induce phagocytes to perform phagocytosis. IL-4 and IL-13 induce antibody production of B cells by activation, and IL-5 activates eosinophils. While IFN-�� promotes the proliferation of Th1 cells, it inhibits Th2 cell proliferation. Conversely, IL-4 induces Th2 cell proliferation and inhibits Th1 cell proliferation (21). The environment of cytokines is determined by the balance between Th1 and Th2 despite a clinical controversy about the balance of Th1 and Th2, (21,22). However, excessively Megestrol Acetate and constitutively produced cytokines are involved in inflammatory diseases, so it is necessary to develop functional food materials for immune modulation (23). In particular, a prevalence of hypersensitive diseases continues to grow in the westernized life pattern, increasing the demand for functional foods that modulate excessively induced cytokines. Healthy foods improve immune function by normalizing the physical state of patients with immunological disorders such as allergies, asthma, or cancer, and they may reduce the risks of developing diseases in healthy individuals. In this clinical study, there was no significant www.selleckchem.com/products/SB-431542.html change in IFN-�� and IL-2 levels before or after taking PLAG, whereas Selleck Ruxolitinib the secretion of IL-4 decreased significantly (p