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Our study serves to highlight how advances in the genomic sciences can influence clinical practice and patient care at an individual level. Presently, it is recommended by the C3 glomerulopathy consensus group that all patients, regardless of being diagnosed with disease affecting the native or transplant kidney, should have serological investigations comprising measurements of serum C3, C4, factor H, paraprotein and C3 nephritic factor. Other tests that should be considered on an individual basis include measurement of serum factor B, C5, markers of C3/C5 activation, anti-factor H antibodies, anti-factor B antibodies and mutation screening of complement regulatory genes (such as CFH, CFI and CD46), activation protein gene (C3, CFB) and copy number variation across the CFH-CFHR locus [4]. These investigations should also be considered in potential living kidney donors Pictilisib research buy with a strong family history. To date, no treatment has been proven to be beneficial in C3 glomerulopathy. The Kidney Disease: Improving Global Outcomes clinical practice guideline for glomerulonephritis recommend that adults or children with presumed idiopathic MPGN accompanied by nephrotic syndrome and progressive decline in kidney function should receive oral cyclophosphamide or MMF with low-dose alternate day or daily corticosteroids with initial therapy limited to Selleck VE 821 of membrane attack complex, as a disease modifying agent. Results from anecdotal cases and open-label studies have shown modest benefits in some patients, although further evidence is awaited [19�C22]. In conclusion, recurrence of disease is common in all forms of C3 glomerulopathy following kidney transplantation. Although disease Azastene recurrence was high in our cohort, overall transplant graft survival was good and transplantation remains a viable treatment option for ESKD secondary to C3 glomerulopathy. Conflict of interest statement None declared.""Dialysis and renal transplantation are life-saving treatments, but they are also demanding and impact appreciably on the everyday lives of end-stage renal disease (ESRD) patients, often negatively affecting emotional and psychological well-being. Many patients find the transition to dialysis frightening and traumatic [1�C3]. They can continue to experience periods of distress throughout their time on dialysis due to the stress of treatment, loss of sexual function, altered body image and decreased physical and cognitive functioning, as well as consequent effects on employment, relationships and lifestyle [4�C7].