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Finally, the economic evaluation presented here is a comparison of direct costs while a full cost effectiveness analysis would inform policy more comprehensively. In summary, rotavirus diarrhea continues to be the most Thalidomide important cause of diarrheal deaths, hospitalizations, and outpatient visits annually for children mTOR inhibitor therapy While phase II/III trials for other candidate vaccines Wortmannin in vitro are ongoing [6], it is important to monitor the burden of rotavirus diarrhea in India to gauge the effectiveness and impact of vaccines, when and where they are used, and possibly to monitor the emergence of strains under vaccine pressure. We conducted a multicenter hospital-based surveillance from July 2009 to June 2012 to determine the burden and molecular epidemiology of diarrheal disease due to rotavirus. The Christian Medical College (CMC), Vellore, Child Jesus Hospital (IJH), Trichy, and St. Stephen's Hospital (SSH), Delhi took part in hospital-based surveillance from July 2009 to June 2012 at CMC and IJH and July 2009 to June 2011 at SSH, following the previously described protocol [2]. Briefly, all children