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��Please take 5 minutes to complete this brief online survey. We recognize that GME training requirements coupled with life outside of GME can be overwhelming. We are interested in learning more about the major life events that residents and fellows experience during their GME training. This may assist GME programs and http://www.selleckchem.com/products/OSI-906.html institutions in better providing support to residents/fellows to ensure a meaningful and successful experience��. We told recipients that their participation was voluntary and that their responses were not intended to be linked to them in any way. We sent a reminder email 2 and 7 days after the initial email. Demographic questions included clinical department, gender, and years of GME training. The graduates were asked about their relationship status and whether they had any children upon entering GME training (Table 1). Graduates were then asked to select from a list of major life events that occurred during their GME training (Table 2). We compiled a CGK 733 list of major life events based on informal discussions between the authors and current GME trainees, with the goal of including a broad range of life events which would have a significant effect on the life of an individual. A follow-up question assessed whether there was a conscious decision to engage, or not engage (when not expected or planned), in any of these activities because they were in a GME training program. Finally, they were asked if any of these life events had a direct impact on their career choice or decision to pursue additional GME training. Responders were also given the option to include MLN0128 order free text comments for each question which were incorporated into the findings when applicable. Table 1 Distribution of demographic information upon entering GME training Table 2 Distribution of life events during GME training Data analysis and management We calculated the distribution of answers in total and for both genders, with differences compared via a Chi-squared analysis. To assess whether there was any influence on the conscious decision during GME training to engage in certain activities, as well as on career choices or additional training a multivariate logistic regression model was created. The study was designed to detect a moderate effect size (f2=0.2) with a power of 0.8 and p-value of 0.05 considered statistically significant. As part of this analysis, several variables were combined due to the low incidence/prevalence (Table 3). GME training programs were categorized into surgical (orthopedic surgery, general surgery, ophthalmology), lifestyle (anesthesiology, dermatology, pathology, radiology, radiation oncology), and clinical (community and family medicine, internal medicine, neurology, obstetrics and gynecology, pediatrics, psychology, combined programs). We performed the statistical analysis utilizing JMP Pro (version 9.0.0, SAS Institute Inc., Cary, NC). We considered a p-value