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The algorithms created in these guidelines support the use of 17-OHPC but not vaginal progesterone in women with a prior spontaneous preterm birth. The reverse is true for women with a short cervix (TRIB1 women with a prior history of preterm birth based on 11 RCTs that included 1899 patients. Progesterone was associated with a reduced risk of preterm birth at buy MK-2206 subgroup was small. In asymptomatic singleton pregnancies with a sonographic short cervix ��25 mm, vaginal progesterone appears to be beneficial in reducing preterm birth and neonatal morbidity and mortality. In an individual patient data meta-analysis of five RCTs (775 women, 827 infants), the rate of early preterm birth at Ibrutinib solubility dmso numbers needed to treat [NNT] 11), the effect being evident regardless of a history of previous preterm birth [22]. Infants of treated women had significantly reduced the risk of respiratory distress syndrome (6.1% vs. 12.5%; RR 0.48; 95% CI 0.30�C0.76), composite neonatal morbidity and mortality (9.7% vs. 17.3%; RR 0.57), and birth weight