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Clinical experience of varenicline for smoking cessation. The Clinical Respiratory Journal 2010; 4: 215�C221. ""Aims:? The purpose of this study was to compare the efficacy of budesonide/formoterol maintenance and reliever therapy (Symbicort? SMART?, AstraZeneca AB, S?dert?lje, Sweden) with conventional best standard treatment (CBST) in patients with persistent asthma in an attempted ��real life�� setting. Methods:? In total, 1835 patients from Denmark, Finland and Norway were randomized to 26 weeks treatment with budesonide/formoterol 160/4,5??g twice daily plus budesonide/formoterol 160/4,5??g IDO inhibitor for symptom relief or CBST according to the Global Initiative for Asthma guidelines. The study was randomized, open-label and designed to reflect ��real life�� asthma management. Efficacy variables were time to first severe asthma exacerbation, rate of severe asthma exacerbations, asthma control (Asthma Control Questionnaire-5) and use of inhaled glucocorticosteroids (IGCS). Results:? Treatment with budesonide/formoterol maintenance and reliever therapy led to a 21% reduction in time to first severe asthma exacerbation compared with CBST, although not statistically significant (hazard ratio 0.794, P?=?0.189). A trend towards a reduction in the rate of severe exacerbations in the budesonide/formoterol maintenance and reliever therapy group was observed (16 vs 22 events/100 patient years; P?=?0.058). The percentage of patients with well-controlled asthma increased significantly MG-132 research buy among those treated with budesonide/formoterol maintenance and reliever therapy compared with CBST (45% vs 40%; odds ATPase ratio 1.39; P?