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02; Table 1). Cerebrovascular conductance index was not altered from rest in the young individuals during either low- or moderate-intensity cycling (��+0.009 �� 0.018 and ?0.019 �� 0.024 cm s?1 mmHg?1, respectively; Fig. 2A). Likewise, no changes in CVCi were observed in the older individuals during low-intensity exercise (��?0.014 �� 0.024 cm s?1 mmHg?1; P= 0.52 versus rest). However, a decrease in CVCi was observed during moderate-intensity exercise in the older subjects (��?0.094 �� 0.029 cm s�C1 mmHg?1; P rest or during GABA activity exercise (P= 0.40), although selleck was slightly but significantly reduced from rest during moderate-intensity exercise (P ALG1 the percentage changes in CCP from rest were greater in the older subjects (Fig. 3B; P= 0.04). Interestingly, the relative change in CCP from rest to each intensity of exercise was not related to the exercise-induced change in MAP in young subjects (low- and moderate-intensity exercise, r= 0.253; P= 0.23), whereas in older subjects the changes in CCP with exercise were related to the changes in MAP (low- and moderate-intensity exercise, r= 0.618; P