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The symptoms in these three patients improved without specific treatment within a few days after discontinuing excimer therapy. At baseline, the mean (��SD) PPPASI score was 19.5 (��8.1) and it decreased steadily throughout the treatment period: 13.2 (��6.6) at 10 treatments, 10.9 (��9.6) at 20 treatments and 9.5 (��8.9) at 30 treatments. PTPRJ The PPPASI score was significantly lower after 20 treatments than at baseline (P?this website in Fig.?S1. The Th17 frequency in the peripheral blood after excimer treatment did not differ significantly from baseline values. In contrast, the Treg frequency increased significantly (P?=?0.004; Fig.?2). Th17 levels were significantly correlated with disease duration (r?=??0.749), but not the PPPASI score (r?=??0.05; Fig. S2). Our results are comparable with those of previous studies (10,11). We used an excimer light with a filter that cuts off wavelengths below 297?nm (2), which seemed to be as effective as other excimer light treatments. Irradiation without wavelengths below 297?nm improves the safety of excimer light treatment. There were no significant changes in Th17 levels after excimer therapy, but the Treg population significantly increased. Treg might better reflect PPP severity than Th17. Th17 levels correlated with the disease duration, which might relate to the pathogenesis in the early stage of this disease. This work was financially supported by a Grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We thank Ms. Nishioka and Ms. Kasuya for technical assistance. T.F, K.T. and A.M. designed Dasatinib price the research and analysed the data. E.N and H.K. recruited the patients and collected the data. S.C. monitored statistical data. T.F. and A.M. wrote the manuscript. The authors declare no conflict of interest. Figure S1. Clinical pictures of patient No.6 at baseline, and after 10, 20 and 30 treatments. Excimer light was sometimes effective already in the early stages. Figure S2. Relationship between PPPASI, Th17 and disease duration. Th17 levels were not significantly correlated with the PPPASI (r?=??0.050), but were significantly correlated with disease duration (r?=??0.749).