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Overexpression of HER2 was significantly associated with p53 protein accumulation (P Thymidine kinase osteosarcoma. (a) Photomicrograph of osteosarcoma (hematoxylin and eosin). Immunohistochemical analysis revealed (b) Ki67 with 30% positivity, and (c) HER2 grade 3+ reactivity. (d) P53 demonstrating clusters of nuclei ... Table 3 Correlation between HER2, p53, and Ki67 expression Disease-free and overall survival was categorized by HER2, p53, and Ki67 expression. HER2 overexpression with P53 were associated with significantly reduced disease-free ( HER2 overexpression with ki67 were associated with significantly reduced disease-free (P see more with p53 protein accumulation and Ki67 expression together. The tumors of 38 patients were positive for both HER2 overexpression and p53 protein accumulation. The disease-free and overall survival curves demonstrate that these patients relapsed and died within a significantly shorter period of time after the surgery [Figures ?[Figures2a2a and ?andb]b] (P selleck inhibitor different from those for patients with tumors that were negative for both HER2 and p53. Figure 2a Effect of coexistence of HER2 overexpression and p53 protein accumulation on (a) disease-free and (b) overall survival among 56 patients with osteosarcoma. Free and overall survival were significantly worse in patients with HER2 and p53-positive tumors ... Figure 2b Effect of coexistence of HER2 overexpression and p53 protein accumulation on (a) disease-free and (b) overall survival among 56 patients with osteosarcoma. Free and overall survival were significantly worse in patients with HER2 and p53-positive tumors ... In our analysis [Table 4], combined HER2 and p53 status (P