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The estimated prevalence of MGUS in individuals �� 50 years old is over 3% in the general Caucasian population [2], and this value increases with age and varies by ethnicity. The overall risk of progression to multiple myeloma, macroglobulinemia, primary amyloidosis, or malignant lymphoma is about 1% per year [3-5]. However, there is a paucity of data addressing the epidemiology and natural course of MGUS in Asians. We previously reported the estimated age- and sexadjusted prevalence of MGUS among 680 responders Baf-A1 in vivo in a Korean elderly urban cohort recruited during 2005-2006 to be 3.3% (95% confidence interval [CI], 2.0% to 4.6%) [6]. Here, we report outcomes of the 5-year follow-up study of MGUS conducted between 2010 and 2011. Materials and Methods The Korean Longitudinal Study on Health and Aging (KLoSHA) is a population-based prospective cohort study of health, aging, and common geriatric diseases in a population �� 65 years in the town of Seongnam-si near Seoul. Out of 1,118 candidates randomly selected from 61,730 individuals in 2005, 714 agreed to participate in the baseline KLoSHA study from 2005-2006. Among them, 680 with available plasma samples were screened for MGUS by immunofixation and free light chain (FLC) assay. These participants were followed, and sera were collected between 2010 and 2011. Follow-up contact was initially Lumacaftor chemical structure made by mail to inform the participants of the study goals, confidentiality, and measures conducted during follow-up evaluations. Approximately 2 weeks later, a KLoSHA investigator contacted participants by telephone. If the participant reacted to neither the initial letter nor the telephone Resminostat call, a staff member personally visited their house. Two-step screening was performed with standard serum electrophoresis followed by immunofixation and determination of the serum concentration of monoclonal- protein (M-protein). The FLC were also measured in all samples. MGUS was defined as the presence of