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However, the overall percentage of D2+ lymphadenectomies was lower in Korean patients due to the lower ratio of advanced gastric cancer in this group. In fact, the benefit of extended D2 lymphadenectomy for gastric cancer remains unclear, although some studies have proposed its use.25,26,27 However, other researchers have contrasting Quinapyramine opinions.28,29,30 While the number of lymph nodes harvested in Korean patients was significantly greater than that in Chinese patients, multivariate analysis showed that this was not an independent risk factor affecting OS and PFS. Therefore, we speculated that the number of lymph nodes harvested and extent of lymphadenectomy might be important for the survival of gastric cancer patients, Neratinib purchase especially those with non-metastatic advanced gastric cancers such as stage III; however, it is probably irrelevant for early stage (stage I, II) and metastatic cancers (stage IV). Moreover, the poorer survival of Chinese patients, particularly those with stage III disease, might also be partially attributed to downstaging31 because of the insufficient number of lymph nodes harvested (approximately 20% of patients had S3I-201 in vivo surgical treatment policies in both countries. Supplementary Material Supplementary Table 1: Surgical characteristics of gastric cancer patients Click here to view.(86K, pdf) Supplementary Table 2: Major surgery-related complications Click here to view.(86K, pdf) Supplementary Table 3: Cox proportional hazards model for OS and PFS Click here to view.(61K, pdf)""As described above, both micrometastasis and ITC cannot be de-tected via a typical pathologic examination, such as H&E staining. Therefore, many studies have been performed to establish effective methods for detecting micrometastasis.20 As a result, some other diagnostic techniques have been introduced to detect lymph node micrometastasis in patients with gastric cancer (Table 1).